Document Detail

A retrospective analysis of obstetric patients with idiopathic thrombocytopenic purpura: a single center study.
MedLine Citation:
PMID:  20882444     Owner:  NLM     Status:  MEDLINE    
Idiopathic thrombocytopenic purpura (ITP) commonly affects women of childbearing age. We studied the clinical characteristics of pregnant women with ITP to estimate their risks of bleeding. A retrospective chart review was performed for all obstetric patients with ITP who had delivery at our hospital, from 1 March 2000 to 31 March 2008. Twenty women with ITP delivered 24 children in 23 pregnancies. In all, eight women were treated with corticosteroid during their pregnancy period, and there was only one non-responder. There was no correlation between the maternal platelet count and the amount of blood loss at delivery. Two infants were revealed to have had platelet counts lower than 30 × 10⁹/L, and were treated with high-dose IV IgG. One of them also received corticosteroid therapy. There was no relationship between maternal platelet count at delivery and infant platelet count at birth. Overall, no serious bleeding event was seen in either of the mothers or infants. For most women with ITP, pregnancy is uncomplicated, and even those with severe thrombocytopenia during pregnancy have good outcomes when under the strict care of a hematologist and gynecologist.
Atsuko Fujita; Rika Sakai; Shiro Matsuura; Wataru Yamamoto; Rika Ohshima; Hideyuki Kuwabara; Mika Okuda; Tsuneo Takahashi; Yoshiaki Ishigatsubo; Shin Fujisawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-30
Journal Detail:
Title:  International journal of hematology     Volume:  92     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-06     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  463-7     Citation Subset:  IM    
Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Delivery, Obstetric
Hemorrhage / etiology*
Infant, Newborn
Platelet Count
Pregnancy Complications, Hematologic / blood*,  drug therapy
Purpura, Thrombocytopenic, Idiopathic / blood*,  drug therapy
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Adrenal Cortex Hormones

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