| A retrospective analysis of fondaparinux versus enoxaparin treatment in women with infertility or pregnancy loss. | |
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MedLine Citation:
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PMID: 19703143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: We compared the pregnancy success rates and safety parameters of fondaparinux versus enoxaparin, combined with immunotherapy, in patients with a history of miscarriage and/or infertility and coagulant defects. METHOD OF STUDY: A total of 127 pregnancies in 110 patients with a history of miscarriage and/or infertility were retrospectively evaluated. Of these, 29 pregnancies used fondaparinux 2.5 mg daily and 98 pregnancies used enoxaparin 30 mg twice daily. RESULTS: The pregnancy success rate was 59% (17/29; 95% CI, 41-75%) for patients receiving fondaparinux and 58% (57/98; 95% CI, 48-68%) for patients receiving enoxaparin. No difference was detected in birth weight (2.7 +/- 0.8 and 2.9 +/- 0.6 kg, respectively) or gestational age at delivery (37.3 +/- 2.2 and 37.7 +/- 2.1 weeks, respectively). No birth defects, severe bleeding-related complications, or serious allergic reactions were observed. CONCLUSION: In patients with a history of miscarriage, infertility, and coagulant defects receiving immunotherapy, fondaparinux resulted in successful pregnancy outcomes comparable with enoxaparin therapy. Although no difference in outcome was observed in our analysis, a much larger study is required to achieve statistical power. |
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Authors:
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Edward E Winger; Jane L Reed |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-08-24 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 62 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-15 Completed Date: 2009-12-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 253-60 Citation Subset: IM |
Affiliation:
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Alan E. Beer Center for Reproductive Immunology & Genetics, San Francisco, CA 94111, USA. ewinger@sbcglobal.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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diagnosis,
immunology,
physiopathology,
therapy* Adult Combined Modality Therapy Enoxaparin / adverse effects, therapeutic use* Female Humans Immunotherapy Infertility, Female / diagnosis, immunology, physiopathology, therapy* Polysaccharides / adverse effects, therapeutic use* Pregnancy Pregnancy Outcome Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Enoxaparin; 0/Polysaccharides; 0/fondaparinux |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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