Document Detail

Retrospective analysis of disease association and outcome in histologically confirmed ischemic colitis.
MedLine Citation:
PMID:  23419044     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify risk factors, clinical features and complications in patients with ischemic colitis (IC).
METHODS: All patients diagnosed with biopsy proven IC within a 2-year period were identified; clinical data were retrospectively collected and subsequently analyzed.
RESULTS: In total, 72 IC patients with a mean age of 68 years were included in this study. Among them, 18 (25.0%) were younger than 65 years with a female predominance. One-third of the patients was found to be without vascular risk factors, and 8 patients met the criteria for irritable bowel syndrome. No history of oral contraceptives or hormonal replacement therapy use could be found among the women diagnosed with IC. Over a mean duration of follow-up of 9.5 months (range 0-65 months), the rate of recurrent disease was 16.7%, while only 2 (2.8%) patients developed extra intestinal vascular sequelae. Statistical analysis identified a history of atrial fibrillation and the use of furosemide to be the only significant predictors of a poor outcome, while coronary artery disease and chronic renal failure predicted recurrence and low platelet count predicted stricture formation.
CONCLUSIONS: Although most patients with IC are elderly and have conventional vascular risk factors, it should also be considered in young patients without vascular risk factors, especially in women, who may have an atypical distribution of the disease. Severe complications and extraintestinal vascular sequelae are rare, however, residual gastrointestinal complaints and recurrent disease are relatively common and there are no reliable predictors of the outcome.
Mahmoud Mosli; Jeremy Parfitt; Jamie Gregor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of digestive diseases     Volume:  14     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-15     Completed Date:  2013-09-30     Revised Date:  2014-06-06    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  238-43     Citation Subset:  IM    
Copyright Information:
© 2013 The Authors. Journal of Digestive Diseases © 2013 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
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MeSH Terms
Aged, 80 and over
Colitis, Ischemic / diagnosis*,  etiology,  therapy
Follow-Up Studies
Intestinal Obstruction / etiology
Middle Aged
Retrospective Studies
Risk Factors
Treatment Outcome
Young Adult
Comment In:
J Dig Dis. 2014 Jun;15(6):331-3   [PMID:  24612474 ]

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