Document Detail


A retrospective analysis of Acute Reference Doses for pesticides evaluated in the European Union.
MedLine Citation:
PMID:  20144134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This retrospective analysis of Acute Reference Doses (ARfD) values is based on pesticides that have been evaluated and peer-reviewed in Europe between 2000 and 2008. The published database of the 198 ARfDs was analysed. For 48% of all substances, no ARfD was considered necessary because of the low acute toxicity of these pesticides. The majority of ARfDs were based on studies that were required for pesticides and conducted for regulatory purposes and in which specific acute alerts were investigated. In less than 10% of cases, conservatively established ARfDs were based on repeated-dose toxicity or multigeneration studies. For 4 of these 198 pesticides, a refinement of a conservative ARfD using an additional toxicity study would be justifiable because a more realistic calculation of the exposure component was not sufficient to eliminate any health concern. In the analysed database, special studies for ARfD refinement were submitted for 8 of the 198 pesticides. They were mostly performed in addition to the basic acute toxicity data requirements, in cases in which it was apparent that the acute intake estimation exceeded a conservatively established ARfD. However, several studies were not accepted by regulatory authorities because of quality deficiencies. The results of this analysis indicate that the development of a harmonised study design that produces consistent and robust toxicological data on the occurrence of acute effects and their dose response would be valuable for setting ARfDs. Such a protocol, plus additional research on the mode of action for acute effects observed in relevant targets for ARfD derivation, is considered as an important prerequisite for an improved acute risk assessment for pesticides.
Authors:
Roland Solecki; Tomas Moeller; Michael Herrmann; Bernd Stein
Related Documents :
23363014 - The effect of calyculin a on the dephosphorylation of the histone γ-h2ax after formati...
23201594 - Rosmarinic acid from eelgrass shows nematicidal and antibacterial activities against pi...
7569674 - Expression of exposure in negative carcinogenicity studies: dose/body weight, dose/body...
24039464 - Bioconversion of straw into improved fodder: preliminary treatment of rice straw using ...
6897204 - Toxicology of amsa in beagle dogs and cdf1 mice.
9058614 - Cidofovir: a new therapy for cytomegalovirus retinitis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical reviews in toxicology     Volume:  40     ISSN:  1547-6898     ISO Abbreviation:  Crit. Rev. Toxicol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914275     Medline TA:  Crit Rev Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  24-34     Citation Subset:  IM    
Affiliation:
Department of Chemical Safety, Federal Institute for Risk Assessment, Berlin, Germany. Roland.Solecki@bfr.bund.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Databases, Factual
European Union
Humans
No-Observed-Adverse-Effect Level
Pesticides / toxicity*
Retrospective Studies
Risk Assessment / methods
Toxicity Tests / methods*
Chemical
Reg. No./Substance:
0/Pesticides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A retrospective analysis of toxicity studies in dogs and impact on the chronic reference dose for co...
Next Document:  The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for ...