| The retinal dehydrogenase/reductase retSDR1/DHRS3 gene is activated by p53 and p63 but not by mutants derived from tumors or EEC/ADULT malformation syndromes. | |
| | |
MedLine Citation:
|
PMID: 20543567 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Retinol and its metabolites have important roles in many processes including embryonic development, cellular differentiation, apoptosis and maintenance of epithelia. Retinal short-chain dehydrogenase/reductase retSDR1, also known as dehydrogenase/reductase member 3 (DHRS3), is involved in maintaining the cellular supply of retinol metabolites. We observe that retSDR1 expression is activated by members of the p53 family. Particularly p53 and TAp63γ regulate transcription through two separate response elements in the retSDR1 promoter. Both proteins bind the promoter in vitro and in vivo. Induction of DNA damage leads to recruitment of p53 and p63 to the retSDR1 promoter. A tumor-derived p53 mutant is unable to activate retSDR1 transcription. As mutants of p63 in humans exhibit phenotypes that cause several autosomal dominantly inherited syndromes leading to developmental malformations, we tested the transcriptional response of TAp63γ mutants derived from the EEC, SHFM and ADULT syndromes. EEC syndrome-specific mutations of TAp63γ fail to transactivate retSDR1 and an ADULT syndrome-derived mutant stimulates retSDR1 transcription significantly less than the wild-type variant of p63. Taken together, the results suggest a potential role of the p53/p63-mediated retSDR1 activation in tumor suppression as well as in developmental processes. |
| | |
Authors:
|
Ralf D Kirschner; Karen Rother; Gerd A Müller; Kurt Engeland |
Related Documents
:
|
21042217 - Nervous system tumors associated with familial tumor syndromes. 19491227 - Mutation in the tbce gene is associated with hypoparathyroidism-retardation-dysmorphism... 11914417 - Progressive bulbospinal amyotrophy in triple a syndrome with aaas gene mutation. 1408197 - Finding the gene(s) for waardenburg syndrome(s). 21463957 - Pediatric intraoperative floppy iris syndrome associated with persistent pupillary memb... 20583147 - Agenesis of the corpus callosum and congenital lymphedema: a novel recognizable syndrome? |
Publication Detail:
|
Type: Journal Article Date: 2010-06-01 |
Journal Detail:
|
Title: Cell cycle (Georgetown, Tex.) Volume: 9 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2011-05-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
|
Languages: eng Pagination: 2177-88 Citation Subset: IM |
Affiliation:
|
University of Leipzig; Leipzig, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The fine line between waste disposal and recycling: DRPLA fly models illustrate the importance of co...
Next Document: Apoptosis induction of ZBB-006, a novel synthetic diterpenoid, in the human hepatocellular carcinoma...