| The retardation of aging by caloric restriction: its significance in the transgenic era. | |
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MedLine Citation:
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PMID: 14698815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The retardation of aging and diseases by caloric restriction (CR) is a widely-studied and robust phenomenon. Recent publications describe transgenic and other mutant rodents displaying lifespan extension, and the rapid pace at which these animals are being generated raises the possibility that the importance of the CR paradigm is declining. Here we discuss these models and evaluate the evidence whether or not the aging process is retarded based on longevity, disease patterns and age-associated biological changes. A comparison to rodents on CR is made. Because CR has been investigated for approximately 70 years with increasing intensity, there exists extensive data to document aging retardation. In contrast, for nearly all of the genetically abnormal models of lifespan extension, such data are minimal and often unconvincing; additional studies will be required to validate these strains as suitable models for aging research. |
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Authors:
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Jamie L Barger; Roy L Walford; Richard Weindruch |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Experimental gerontology Volume: 38 ISSN: 0531-5565 ISO Abbreviation: Exp. Gerontol. Publication Date: 2003 Nov-Dec |
Date Detail:
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Created Date: 2003-12-30 Completed Date: 2004-05-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
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Languages: eng Pagination: 1343-51 Citation Subset: IM |
Affiliation:
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Wisconsin Primate Research Center and Department of Medicine, University of Wisconsin Madison, Madison, WI 53705, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Caloric Restriction* Longevity / physiology Mice Mice, Mutant Strains Mice, Transgenic Models, Animal* Models, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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P01 AG11915/AG/NIA NIH HHS; R01 AG18922/AG/NIA NIH HHS; T32AG00213/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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