| A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. | |
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MedLine Citation:
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PMID: 22326393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Among the seven natural resveratrol analogs separated and identified from Pholidota yunnanensis R(OLFE), we found phoyunbene B (PYB, trans-3,4'-dihydroxy-2',3',5-trimethoxystilbene) was more effective in inhibiting the growth of HepG2 hepatocellular carcinoma cells than resveratrol. The inhibitory effect of PYB in HepG2 cells was due to its induction of G2/M cell cycle arrest and apoptosis. Induction of G2/M phase cell cycle arrest by PYB was associated with its up-regulation of Cyclin B1, while its induction of apoptosis was accompanied with its down-regulation of Bcl-2 and up-regulation of Bax. Our in vitro invasion/migration assays also showed that PYB could inhibit the invasion of hepatocellular carcinoma cells. |
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Authors:
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Guanghui Wang; Xiaoyu Guo; Haifeng Chen; Ting Lin; Yang Xu; Quancheng Chen; Jie Liu; Jinzhang Zeng; Xiao-Kun Zhang; Xinsheng Yao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-01-16 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 22 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-21 Completed Date: 2012-06-18 Revised Date: 2013-01-17 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 2114-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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School of Pharmaceutical Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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chemistry*,
isolation & purification,
pharmacology* Apoptosis / drug effects Carcinoma, Hepatocellular / drug therapy* G2 Phase Cell Cycle Checkpoints / drug effects* Hep G2 Cells Humans Liver Neoplasms / drug therapy* M Phase Cell Cycle Checkpoints / drug effects Orchidaceae / chemistry Stilbenes / chemistry*, isolation & purification, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA140980/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Stilbenes; 0/trans-3,4'-dihydroxy-2',3',5-trimethoxystilbene; 501-36-0/resveratrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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