Document Detail


The results of purified protein derivative test in ankylosing spondylitis patients: clinical features, HRCT results and relationship with TNF-blocker usage.
MedLine Citation:
PMID:  18682953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we evaluated the clinical features, treatment modalities, including TNF-blockers, purified protein derivative (PPD) test, chest X-ray and HRCT results in our AS patients. We evaluated the clinical features, disease activity and PPD results in 88 AS patients (72 males, 16 females, mean age: 38.3+/-10) diagnosed at our center. 119 RA, 28 SLE and 27 gouty arthritis patients followed up at the same time period were taken as the control group. The mean disease duration in AS patients was 12.6+/-8.3 years. The frequency of PPD positivity in AS patients (77.3%) was similar to that in gouty arthritis (70.4%) patients; and significantly higher than the frequency in SLE (21.4%) and RA (35.3%) patients (P values<0.001). There was a chest X-ray abnormality in 20 AS patients (22.7%). When subjects (11 patients, 12.5%) with apical fibrosis, aspergillosis, previous or active TB on chest X-ray and/or HRCT were compared to others; it was observed that they were older (P<0.001), had longer disease duration (P=0.006); and less chest expansion (P=0.01). Fifty patients were administered TNF-blockers. The PPD test was positive in 38 of patients (76%) using TNF-blockers. All of these patients were given isoniazid prophylaxis. After a median follow up of 18 months, TB did not develop. In Turkey which is a country with a relatively high incidence of TB, in spite of a higher frequency of PPD positivity in AS patients compared to RA and SLE patients, TNF-blockers did not result in any TB with suitable prophylaxis.
Authors:
Omer Nuri Pamuk; Yusuf Yesil; Salim Donmez; Ercüment Unlü; Ibrahim Hakki Köker; Necati Cakir
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Publication Detail:
Type:  Journal Article     Date:  2008-08-06
Journal Detail:
Title:  Rheumatology international     Volume:  29     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-31     Completed Date:  2009-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  179-83     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, Trakya University Medical Faculty, 22030, Edirne, Turkey. omernpamuk@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibodies, Monoclonal / immunology,  therapeutic use*
Antitubercular Agents / therapeutic use
Arthritis, Gouty / immunology
Arthritis, Rheumatoid / immunology
Female
Humans
Isoniazid / therapeutic use
Lupus Erythematosus, Systemic / immunology
Male
Middle Aged
Radiography, Thoracic
Spondylitis, Ankylosing / diagnosis,  drug therapy,  immunology*
Tomography, X-Ray Computed / methods*
Tuberculin Test
Tuberculosis, Pulmonary / diagnosis,  drug therapy,  immunology*
Tumor Necrosis Factor-alpha / antagonists & inhibitors*,  immunology
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antitubercular Agents; 0/Tumor Necrosis Factor-alpha; 54-85-3/Isoniazid

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