Document Detail

The results of in vitro fertilization-embryo transfer in couples with unexplained infertility failing to conceive with superovulation and intrauterine insemination.
MedLine Citation:
PMID:  7789586     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the results of IVF-ET in couples with long-standing unexplained infertility who had failed to conceive with four to six cycles of superovulation and IUI. DESIGN: Retrospective case control series. SETTING: University IVF-ET center. PATIENTS: One hundred seventeen couples with unexplained infertility who had failed to conceive with superovulation and IUI underwent 157 cycles of IVF-ET. Results were compared with 194 tubal factor couples subjected to 250 IVF-ET cycles within the same time period. RESULTS: Total fertilization failure events were more common (20.4% versus 7.6%) and tended to be repetitive in couples with unexplained infertility. When total fertilization failure events were excluded, fertilization rates (57.8% versus 60.9%) and cumulative clinical pregnancy rates over three cycles (55.4% versus 46.5%) were similar in unexplained infertility and tubal disease groups. CONCLUSIONS: Couples with unexplained infertility failing to conceive with superovulation and IUI have a favorable outcome when treated subsequently with IVF-ET. Conception rates similar to couples with tubal disease may be expected despite a higher incidence of total fertilization failure events.
T Gürgan; B Urman; H Yarali; H A Kişnişçi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  64     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-07-25     Completed Date:  1995-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  93-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Hacettepe, Ankara, Turkey.
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MeSH Terms
Embryo Transfer*
Fallopian Tubes
Fertilization in Vitro*
Infertility / therapy*
Infertility, Female / therapy
Insemination, Artificial, Homologous
Retrospective Studies
Treatment Failure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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