Document Detail


The results of animal studies with ciprofibrate, a new orally effective hypolipidemic drug.
MedLine Citation:
PMID:  454514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Findings are given to show that ciprofibrate, a new orally active phenoxyisobutyrate, is significantly more hypolipidemic than is the reference clofibrate. In hyperlipidemic rats ciprofibrate suppresses the increase in blood lipids 33% at a daily dosage of 0.6--3 mg/kg. The corresponding dosage for clofibrate is 125--460 mg/kg. Based on studies with cholesterol pools pre-labeled with [14C]mevalonate or with cholesterol-labeled pools in ciprofibrate-treated normolipidemic rats, ciprofibrate was shown to inhibit cholesterol biosynthesis. No evidence of the presence of 7- or 24-dehydrocholesterol was obtained in the sera of ciprofibrate-treated rats as shown by gas chromatography examination. The order of hypolipidemic effectiveness of ciprofibrate in hyperlipidemic rats provides a basis for anticipating that ciprofibrate will be hypolipidemic in hyperlipoproteinemic subjects who are considered at high risk of acquiring coronary artery disease.
Authors:
A Arnold; J P McAuliff; L G Powers; D K Phillips; A L Beyler
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  32     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-08-29     Completed Date:  1979-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  155-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Anticholesteremic Agents / therapeutic use
Antilipemic Agents / administration & dosage,  therapeutic use*
Cholesterol / biosynthesis,  blood
Clofibrate / analogs & derivatives*,  therapeutic use
Cyclopropanes / therapeutic use
Drug Evaluation, Preclinical
Hyperlipidemias / drug therapy*
Male
Rats
Triglycerides / antagonists & inhibitors,  blood
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Antilipemic Agents; 0/Cyclopropanes; 0/Triglycerides; 57-88-5/Cholesterol; 637-07-0/Clofibrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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