Document Detail


MODS/SIRS: result of an overwhelming inflammatory response?
MedLine Citation:
PMID:  8662124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple organ dysfunction syndrome and the systemic inflammatory response syndrome are expressions of an inappropriate, generalized inflammatory response to severe inflammatory stimuli, which may be bacterial or nonbacterial in nature. The clinical signs and symptoms, morphologic alterations, and changes in oxygen transport seem to be the direct effect of phagocyte activation. So far, identifying the microorganisms and neutralizing their toxins has not been helpful in improving prognosis. As an essential adjunct to treating the bacterial or nonbacterial causes, finding safe ways of modulating the phagocyte response should be considered.
Authors:
R J Goris
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  World journal of surgery     Volume:  20     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-08-05     Completed Date:  1996-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  418-21     Citation Subset:  IM    
Affiliation:
Department of Surgery, University Hospital Nijmegen, 6500 HB Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Endotoxins / blood
Humans
Inflammation Mediators / physiology*
Multiple Organ Failure / physiopathology*,  therapy
Oxygen / physiology
Phagocytosis / physiology
Prognosis
Systemic Inflammatory Response Syndrome / physiopathology*,  therapy
Chemical
Reg. No./Substance:
0/Endotoxins; 0/Inflammation Mediators; 7782-44-7/Oxygen
Comments/Corrections
Comment In:
World J Surg. 1997 Mar-Apr;21(3):344   [PMID:  9157725 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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