| A restricted cubic spline approach to assess the association between high fat fish intake and red blood cell EPA + DHA content. | |
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MedLine Citation:
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PMID: 20875947 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Fish, especially fatty fish, are the main contributor to eicosapentaenoic (EPA) and docosahexaenoic (DHA) intake. EPA and DHA concentrations in red blood cells (RBC) has been proposed as a cardiovascular risk factor, with <4% and >8% associated with the lowest and greatest protection, respectively. The relationship between high fat fish (HFF) intake and RBC EPA + DHA content has been little investigated on a wide range of fish intake, and may be non-linear. We aimed to study the shape of this relationship among high seafood consumers. METHODS AND RESULTS: Seafood consumption records and blood were collected from 384 French heavy seafood consumers and EPA and DHA were measured in RBC. A multivariate linear regression was performed using restricted cubic splines to consider potential non-linear associations. Thirty-six percent of subjects had an RBC EPA + DHA content lower than 4% and only 5% exceeded 8%. HFF consumption was significantly associated with RBC EPA + DHA content (P [overall association] = 0.021) adjusted for sex, tobacco status, study area, socioeconomic status, age, alcohol, other seafood, meat, and meat product intakes. This relationship was non-linear: for intakes higher than 200 g/wk, EPA + DHA content tended to stagnate. Tobacco status and fish contaminants were negatively associated with RBC EPA + DHA content. CONCLUSION: Because of the saturation for high intakes, and accounting for the concern with exposure to trace element contaminants, intake not exceeding 200 g should be considered. |
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Authors:
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V Sirot; C Dumas; L Desquilbet; F Mariotti; P Legrand; D Catheline; J-C Leblanc; I Margaritis |
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Publication Detail:
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Type: Journal Article Date: 2010-09-28 |
Journal Detail:
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Title: Nutrition, metabolism, and cardiovascular diseases : NMCD Volume: 22 ISSN: 1590-3729 ISO Abbreviation: Nutr Metab Cardiovasc Dis Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111474 Medline TA: Nutr Metab Cardiovasc Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 318-26 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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AFSSA (French Food Safety Agency), 27 avenue du Général Leclerc, F-94701 Maisons-Alfort, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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