Document Detail

The resting interstitial tissue pressure in primary varicose veins.
MedLine Citation:
PMID:  2313829     Owner:  NLM     Status:  MEDLINE    
In 31 patients with unilateral primary varicose veins the resting interstitial pressure in the deep posterior compartment of the leg was measured in three groups: I, asymptomatic; II, symptomatic; III, symptomatic with trophic changes. Spinal anesthesia was induced in all patients, and polytetrafluoroethylene (Teflon) catheters were inserted into the deep posterior compartment of both legs. The interstitial pressure was recorded with a bioelectronic strain-guage pressure monitor with the patient in the horizontal position with complete muscle relaxation. In control legs (n = 31) mean pressure was -2.48 mm Hg (range -5 to 1). However, the measurement in affected legs (n = 31) was significantly higher at 4.61 mm Hg (range 1 to 12). Results demonstrate the following: (1) Primary varicose veins (an exclusively epifascial abnormality) were consistently associated with an increased resting interstitial pressure of the subfascial tissues in the supramalleolar area of the leg. (b) The subfascial resting interstitial pressure was elevated in all stages of varicose veins, even those with short duration of the disease and with no symptoms at all. (c) In all three groups there was a significant increase in the subfascial interstitial pressure between the affected and contralateral extremity. In patients with trophic changes (group III) this increase was significantly higher than in the remaining groups, although there was no significant difference between the increased pressure of the remaining groups (groups I & II).
J J Pflug; D P Zubac; D R Kersten; N D Alexander
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  11     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-20     Completed Date:  1990-04-20     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  411-7     Citation Subset:  IM    
Department of Surgery, Hammersmith Hospital, London, England.
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MeSH Terms
Capillary Permeability / physiology
Edema / physiopathology
Extracellular Space / physiology
Middle Aged
Varicose Veins / physiopathology*
Reg. No./Substance:

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