| The response to long-term overfeeding in identical twins. | |
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MedLine Citation:
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PMID: 2336074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We undertook this study to determine whether there are differences in the responses of different persons to long-term overfeeding and to assess the possibility that genotypes are involved in such differences. After a two-week base-line period, 12 pairs of young adult male monozygotic twins were overfed by 4.2 MJ (1000 kcal) per day, 6 days a week, for a total of 84 days during a 100-day period. The total excess amount each man consumed was 353 MJ (84,000 kcal). During overfeeding, individual changes in body composition and topography of fat deposition varied considerably. The mean weight gain was 8.1 kg, but the range was 4.3 to 13.3 kg. The similarity within each pair in the response to overfeeding was significant (P less than 0.05) with respect to body weight, percentage of fat, fat mass, and estimated subcutaneous fat, with about three times more variance among pairs than within pairs (r approximately 0.5). After adjustment for the gains in fat mass, the within-pair similarity was particularly evident with respect to the changes in regional fat distribution and amount of abdominal visceral fat (P less than 0.01), with about six times as much variance among pairs as within pairs (r approximately 0.7). We conclude that the most likely explanation for the intrapair similarity in the adaptation to long-term overfeeding and for the variations in weight gain and fat distribution among the pairs of twins is that genetic factors are involved. These may govern the tendency to store energy as either fat or lean tissue and the various determinants of the resting expenditure of energy. |
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Authors:
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C Bouchard; A Tremblay; J P Després; A Nadeau; P J Lupien; G Thériault; J Dussault; S Moorjani; S Pinault; G Fournier |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The New England journal of medicine Volume: 322 ISSN: 0028-4793 ISO Abbreviation: N. Engl. J. Med. Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-06-11 Completed Date: 1990-06-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1477-82 Citation Subset: AIM; IM |
Affiliation:
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Physical Activity Sciences Laboratory, Laval University, Ste. Foy, PQ, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Composition* Energy Intake Humans Hyperphagia* Male Obesity / genetics Twins* Twins, Monozygotic* Weight Gain* |
| Grant Support | |
ID/Acronym/Agency:
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DK 34624/DK/NIDDK NIH HHS |
| Comments/Corrections | |
Comment In:
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N Engl J Med. 1990 Oct 11;323(15):1067-9
[PMID:
2215567
]
N Engl J Med. 1990 May 24;322(21):1522-4 [PMID: 2104505 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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