Document Detail


The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud's phenomenon secondary to collagenosis.
MedLine Citation:
PMID:  16363279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Prostanoids are used in the treatment of Raynaud's phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual.
PATIENTS AND METHODS: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud's phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables).
RESULTS: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud's phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6.
CONCLUSION: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud's phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.
Authors:
S Drinda; T Neumann; G Pöhlmann; H Vogelsang; G Stein; G Wolf; G Hein
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  34     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-20     Completed Date:  2006-01-20     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  243-9     Citation Subset:  IM    
Affiliation:
Division of Rheumatology and Osteology, Department of Clinical Medicine III, Friedrich Schiller University Jena, Germany. stefan.drinda@med.uni-jena.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Flow Velocity / drug effects
Collagen Diseases / complications,  drug therapy*,  physiopathology*
Cross-Over Studies
Cytokines / immunology
Female
Humans
Injections, Intravenous
Male
Middle Aged
Prostaglandins / administration & dosage*
Raynaud Disease / drug therapy*,  etiology,  physiopathology*
Skin / blood supply*,  drug effects*,  immunology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cytokines; 0/Prostaglandins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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