Document Detail

The response of plasma interleukin-6 and its soluble receptors to exercise in the cold in humans.
MedLine Citation:
PMID:  18569558     Owner:  NLM     Status:  MEDLINE    
In this study, we wished to determine whether the changes in metabolism observed during exercise in the cold are associated with changes in interleukin-6 (IL-6) and/or its soluble receptors. Eight healthy male participants performed 1 h of cycling exercise at 70% VO2max in a control (20 degrees C) and cold (0 degrees C) environment. Plasma concentrations of IL-6, soluble IL-6 receptor (sIL-6R), and sgp130 were measured before exercise, at 30 and 60 min of exercise, and 60 min after exercise. Substrate oxidation was estimated through measures of pulmonary gas exchange recorded between 50 and 55 min of cycling. Exercise in the cold resulted in an increase (P < 0.05) in carbohydrate oxidation (mean 2.58 g.min(-1), s = 0.49 at 20 degrees C vs. 2.85 g.min(-1), s = 0.58 at 0 degrees C) and a decrease (P < 0.05) in fat oxidation (0.55 g.min(-1), s = 0.17 at 20 degrees C vs. 0.38 g.min(-1), s = 0.16 at 0 degrees C) compared with the control trial. Interleukin-6 concentrations were elevated (P < 0.05) after 60 min of exercise in both the cold and control trials, with no differences between trials at any instant. Neither sIL-6R nor sgp130 was affected by exercise or the environment. The alterations in carbohydrate and fat utilization during 1 h of exercise in the cold are not paralleled by changes in plasma concentrations of IL-6 or its soluble receptors.
Stephen Patterson; Suzanne Reid; Stuart Gray; Myra Nimmo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of sports sciences     Volume:  26     ISSN:  0264-0414     ISO Abbreviation:  J Sports Sci     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-11-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8405364     Medline TA:  J Sports Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  927-33     Citation Subset:  IM    
School of Sport and Exercise Sciences, Loughborough University, Loughborough, UK.
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MeSH Terms
Analysis of Variance
Carbohydrate Metabolism
Cold Temperature*
Enzyme-Linked Immunosorbent Assay
Exercise / physiology*
Fats / metabolism
Interleukin-6 / blood*
Receptors, Interleukin-6 / blood*
Reg. No./Substance:
0/Fats; 0/Interleukin-6; 0/Receptors, Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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