Document Detail


The response of normal and ataxia-telangiectasia cells to bleomycin: relationships between chromosome damage, cell cycle delay and cell killing.
MedLine Citation:
PMID:  2410788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In agreement with our earlier observation (Scott and Zampetti-Bosseler, 1982) on X-irradiated normal and ataxia-telangiectasia (A-T) fibroblasts, we now report that after bleomycin or neocarzinostatin treatment also, A-T cells exhibit less G2 delay than normal cells. We confirm that A-T cells sustain more chromosome damage and lethality than normal cells after bleomycin. These observations support the hypothesis (Painter and Young, 1980) that A-T cells are defective in the recognition of certain lesions which normally lead to delays in progression through the cell cycle, during which they are repaired, and which, if unrepaired, lead to cell-lethal chromosome damage. However, we find that after bleomycin, as opposed to X-rays, the contribution of this type of lesion to cell death is minimal. The predominant lesions leading to cell death after bleomycin are not manifested at chromosome aberrations and do not lead to G2 delay or DNA-synthesis inhibition. A-T cells are defective in the recognition and/or repair of both types of lesion.
Authors:
F Zampetti-Bosseler; D Scott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  151     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-04     Completed Date:  1985-09-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Ataxia Telangiectasia / genetics*
Bleomycin / toxicity*
Cell Cycle / drug effects
Cell Survival / drug effects
Chromosome Aberrations
Chromosomes / drug effects*
DNA Repair / drug effects
DNA Replication / radiation effects
Humans
Interphase / radiation effects
Mutation / drug effects
Zinostatin / toxicity
Chemical
Reg. No./Substance:
11056-06-7/Bleomycin; 9014-02-2/Zinostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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