Document Detail


The response of hepatocyte cell volume to hyperthermia and its role in oedema.
MedLine Citation:
PMID:  22255292     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel mathematical model for hepatocytes and surrounding volume is presented here; in addition to tracking ion transport and diffusion the new model allows for changing cell volume. Using temporally and spatially varying temperature as an input, this paper shows how differences between diffusion coefficients directly influence increases in cell volume. The multiscale nature of the model presents a possible link from established cellular equations to the observed clinical result of oedema present in thermal treatments of cancer.
Authors:
D P O'Neill; T Peng; S J Payne
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2011     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2011  
Date Detail:
Created Date:  2012-01-18     Completed Date:  2012-07-09     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4305-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Size*
Edema / pathology*
Fever / pathology*
Humans
Models, Theoretical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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