Document Detail

The response of hepatic angiotensinogen secretion to experimental inflammatory stimuli. A comparison with acute-phase proteins.
MedLine Citation:
PMID:  7692708     Owner:  NLM     Status:  MEDLINE    
Angiotensinogen is thought to be an acute-phase protein, since its plasma concentrations increase in response to some inflammatory conditions, e.g. partial hepatectomy, nephrectomy or lipopolysaccharide (LPS) injection. However, this response of angiotensinogen has never been related to that of established acute-phase proteins. We have, therefore, examined plasma concentrations and hepatic secretion of angiotensinogen in two widely used inflammation models, i.e. turpentine or LPS injection in the rat, as well as in nephrectomized and sham-nephrectomized rats, in comparison to the response of two established acute-phase proteins, alpha 1-acid glycoprotein (AGP) and alpha 2-macroglobulin (AMG). Plasma concentrations and secretion rates of AGP and AMG increased significantly in all the conditions examined. The magnitude of the response decreased in the order turpentine > nephrectomy = LPS > sham nephrectomy. Angiotensinogen secretion was stimulated in LPS-injected (2.5-fold) and nephrectomized rats (2.6-fold), whereas no changes were seen in sham-nephrectomized rats. Surprisingly, a significant decrease both in secretion rates and plasma concentrations of angiotensinogen occurred in turpentine-injected rats. Intraperitoneal injection of interleukin 6, a major inductor of hepatic acute-phase proteins, increased plasma concentrations and hepatic secretion rates of AGP, AMG and angiotensinogen. Changes in liver angiotensinogen mRNA correlated well with angiotensinogen secretion rates in all groups, indicating that alterations in angiotensinogen synthesis are responsible for the observed changes in secretion rates and plasma concentrations. The response of angiotensinogen to turpentine is difficult to reconcile with the conventional definition of an acute-phase protein.
C Klett; E Hackenthal
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Agents and actions     Volume:  38     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-11-05     Completed Date:  1993-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  220-30     Citation Subset:  IM    
Department of Pharmacology, University of Heidelberg, FRG.
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MeSH Terms
Angiotensinogen / blood,  genetics,  secretion*
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Inflammation / blood,  chemically induced,  metabolism*
Injections, Intraperitoneal
Interleukin-6 / pharmacology
Lipopolysaccharides / toxicity
Liver / drug effects*,  metabolism
Orosomucoid / metabolism,  secretion*
Rats, Sprague-Dawley
Renin / blood
Turpentine / toxicity
alpha-Macroglobulins / metabolism,  secretion*
Reg. No./Substance:
0/Interleukin-6; 0/Lipopolysaccharides; 0/Orosomucoid; 0/alpha-Macroglobulins; 11002-13-4/Angiotensinogen; 8006-64-2/Turpentine; EC

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