Document Detail


'On' response defect in paraneoplastic night blindness with cutaneous malignant melanoma.
MedLine Citation:
PMID:  1544774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Response properties of rod and cone systems were assessed in a patient with an acquired form of night blindness associated with a metastatic cutaneous malignant melanoma. The night blindness, a sensation of shimmering lights, and selective reductions in the amplitudes of both rod and cone electroretinographic (ERG) b-waves were present before and after chemotherapy, confirming that this disorder was a paraneoplastic consequence of the melanoma rather than a response to chemotherapy. During ERG testing with flashes of extended duration, the cone b-wave abnormality was found to be a predominant loss of the cone ERG "on" response with relative preservation of the "off" response, similar to that observed in patients with congenital stationary night blindness. An impairment in signal transmission specific for retinal "on" pathways may be a primary defect in both of these forms of night blindness.
Authors:
K R Alexander; G A Fishman; N S Peachey; A L Marchese; M O Tso
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  33     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-13     Completed Date:  1992-04-13     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  477-83     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Dark Adaptation
Electroretinography
Humans
Light
Male
Melanoma / complications*,  drug therapy
Middle Aged
Night Blindness / etiology*,  physiopathology
Paraneoplastic Syndromes / complications*,  physiopathology
Photic Stimulation
Photoreceptor Cells / physiopathology*
Retinal Diseases / physiopathology
Sensory Thresholds
Signal Transduction
Skin Neoplasms / complications*,  drug therapy
Vincristine / therapeutic use
Grant Support
ID/Acronym/Agency:
EY01792/EY/NEI NIH HHS; EY01903/EY/NEI NIH HHS; EY08301/EY/NEI NIH HHS; P30 EY001792/EY/NEI NIH HHS; R01 EY008301/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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