Document Detail

The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men.
MedLine Citation:
PMID:  19527938     Owner:  NLM     Status:  MEDLINE    
The formation of an interleukin-6/IL-6 receptor (IL-6/IL-6R) complex increases the biological activity and half-life of IL-6, with its response to exercise currently unknown. The aim of the present study was to determine the response of circulating levels of the IL-6/IL-6R complex to exercise. Nine healthy male participants performed 1h of cycling exercise at a workload required to elicit 90% lactate threshold. Venous blood samples were taken at rest, immediately post-exercise and after 1.5 h rest. Hemoglobin concentration and hematocrit were measured to estimate changes in plasma volume during exercise. The concentrations of IL-6, sIL-6R and the IL-6/IL-6R complex were measured via ELISA and corrected for changes in plasma volume. A single bout of acute exercise resulted in a 5-fold increase (P<0.05) in IL-6 and a 1.2-fold increase (P<0.05) in sIL-6R immediately after exercise. These returned to baseline at 1.5 h after the cessation of exercise. There was a 2.1-fold increase (P<0.05) in the levels of the IL-6/IL-6R complex post-exercise with levels remaining 1.8 times elevated (P<0.05) after 1.5 h rest. The present study has demonstrated, for the first time, that circulating levels of the IL-6/IL-6R complex are increased in response to acute exercise in young males.
S R Gray; M Clifford; R Lancaster; M Leggate; M Davies; M A Nimmo
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Publication Detail:
Type:  Journal Article     Date:  2009-06-13
Journal Detail:
Title:  Cytokine     Volume:  47     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-11-12     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  98-102     Citation Subset:  IM    
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MeSH Terms
Interleukin-6 / blood*
Receptors, Interleukin-6 / blood*
Grant Support
G0502250//Medical Research Council
Reg. No./Substance:
0/Interleukin-6; 0/Receptors, Interleukin-6

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