Document Detail

The response of central glia to peripheral nerve injury.
MedLine Citation:
PMID:  8457900     Owner:  NLM     Status:  MEDLINE    
Microglial and astroglial cells undergo prompt responses to peripheral motor and sensory axon injury. These responses include proliferation of microglial cells as well as hypertrophy and increased levels of glial fibrillary acidic protein around the axotomized motoneurons and in the central projection territories of peripherally axotomized sensory ganglion cells. Proliferating microglial cells migrate towards reacting motoneurons, however, without directly apposing their cell membrane. Astroglial cells, on the other hand, increase their structural interrelationship with reacting motoneurons, seemingly at the expense of some presynaptic terminals. In sensory projection areas, microglial cells phagocytose degenerating axons and terminals. Beyond these observations, the functional role of the central glial cell response to peripheral nerve injury is obscure.
M Svensson; P Eriksson; J K Persson; C Molander; J Arvidsson; H Aldskogius
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Brain research bulletin     Volume:  30     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1993  
Date Detail:
Created Date:  1993-04-27     Completed Date:  1993-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  499-506     Citation Subset:  IM    
Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Axons / physiology
Brain / physiology*
Ganglia / physiology*
Motor Neurons / physiology*,  ultrastructure
Neural Pathways / physiology
Neuroglia / physiology*
Peripheral Nerves / injuries*

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