Document Detail

The response of GFR to amino acids differs between autosomal dominant polycystic kidney disease (ADPKD) and glomerular disease.
MedLine Citation:
PMID:  1320229     Owner:  NLM     Status:  MEDLINE    
We compared the glomerular filtration rate (GFR) response to amino acids in patients with glomerular disease and polycystic kidney disease. The GFR response to infusion of amino acids (75 g/12 h), of dopamine (2 micrograms/kg per min), or their combination was evaluated in nine healthy probands and in patients with two types of renal diseases at various degrees of renal function: 15 patients with ADPKD and 11 patients with glomerular disease (IgA glomerulonephritis or diabetic nephropathy). Steady-state inulin infusion technique was used. In healthy subjects amino acids increased median C(in) in response to amino acids was not found in glomerular disease. In contrast in most ADPKD patients median C(in) increased after amino acids (+6.0 ml/min; range -4 to +68), (P less than 0.05). The response to amino acids was not modified by dopamine. The results demonstrate that amino acid-induced acute changes of glomerular filtration differ in polycystic kidney disease compared with glomerular disease. These observations may have implications with respect to mechanisms of progression.
M Zeier; M Schmid; R Nowack; S Zacharewics; C Hasslacher; E Ritz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  7     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1992  
Date Detail:
Created Date:  1992-08-04     Completed Date:  1992-08-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  501-6     Citation Subset:  IM    
Department of Internal Medicine, University of Heidelberg, Germany.
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MeSH Terms
Amino Acids / pharmacology*
Diabetic Nephropathies / physiopathology*
Glomerular Filtration Rate / drug effects*
Glomerulonephritis, IGA / physiopathology*
Hemodynamics / drug effects
Polycystic Kidney Diseases / physiopathology*
Sodium / urine
Reg. No./Substance:
0/Amino Acids; 7440-23-5/Sodium
Comment In:
Nephrol Dial Transplant. 1992;7(12):1254   [PMID:  1337169 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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