| The resistive and elastic work of breathing during exercise in patients with chronic Heart Failure. | |
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MedLine Citation:
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PMID: 22034652 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Patients with Heart Failure (HF) display numerous derangements in ventilatory function, which together serve to increase the work of breathing (Wb) during exercise. However, the extent to which the resistive and elastic properties of the respiratory system contribute to the higher Wb in these patients is unknown.We quantified the resistive and elastic Wb in patients with stable HF (n=9, NYHA I-II) and healthy control subjects (n=9) at standardised minute ventilations during graded exercise. Dynamic lung compliance was systematically lower for a given level of minute ventilation in HF patients than controls (P<0.05). HF patients displayed slightly higher levels of inspiratory elastic Wb, with greater amounts of ventilatory constraint and resistive Wb than control subjects during exercise (P<0.05).Our data indicates that the higher Wb in HF patients is primarily due to a greater resistive- rather than elastic-load to breathing. The greater resistive Wb in these patients likely reflects an increased hysteresivity of the airways and lung tissues. The marginally higher inspiratory elastic Wb observed in HF patients appears related to a combined decrease in the compliances of the lungs and chest wall. The clinical and physiological implications of our findings are discussed. |
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Authors:
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T J Cross; S Sabapathy; K C Beck; N R Morris; B D Johnson |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-27 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Mayo Clinic, Rochester, MN, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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