| A requirement for neuropilin-1 in embryonic vessel formation. | |
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MedLine Citation:
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PMID: 10518505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuropilin-1 is a membrane protein that is expressed in developing neurons and functions as a receptor or a component of the receptor complex for the class 3 semaphorins, which are inhibitory axon guidance signals. Targeted inactivation of the neuropilin-1 gene in mice induced disorganization of the pathway and projection of nerve fibers, suggesting that neuropilin-1 mediates semaphorin-elicited signals and regulates nerve fiber guidance in embryogenesis. Neuropilin-1 is also expressed in endothelial cells and shown to bind vascular endothelial growth factor (VEGF), a potent regulator for vasculogenesis and angiogenesis. However, the roles of neuropilin-1 in vascular formation have been unclear. This paper reported that the neuropilin-1 mutant mouse embryos exhibited various types of vascular defects, including impairment in neural vascularization, agenesis and transposition of great vessels, insufficient aorticopulmonary truncus (persistent truncus arteriosus), and disorganized and insufficient development of vascular networks in the yolk sac. The vascular defects induced by neuropilin-1 deficiency in mouse embryos suggest that neuropilin-1 plays roles in embryonic vessel formation, as well as nerve fiber guidance. |
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Authors:
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T Kawasaki; T Kitsukawa; Y Bekku; Y Matsuda; M Sanbo; T Yagi; H Fujisawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 126 ISSN: 0950-1991 ISO Abbreviation: Development Publication Date: 1999 Nov |
Date Detail:
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Created Date: 1999-12-16 Completed Date: 1999-12-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 4895-902 Citation Subset: IM |
Affiliation:
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Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa-ku, Nagoya 464-8602, Japan. fujisawa@bio.nagoya-u.ac.jp. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessels / abnormalities*, embryology* Central Nervous System / blood supply* Chromosome Mapping* Chromosomes Fetal Heart / abnormalities Mice Mice, Inbred ICR Mice, Mutant Strains Nerve Tissue Proteins / genetics*, metabolism Neuropilin-1 Peripheral Nervous System / blood supply Yolk Sac / abnormalities, blood supply |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; 144713-63-3/Neuropilin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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