Document Detail


The requirement of CD80, CD86, and ICAM-1 on the ability of adjuvant formulations to potentiate antibody responses to a Plasmodium falciparum blood-stage vaccine.
MedLine Citation:
PMID:  18006124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many adjuvants are known to enhance expression of co-stimulatory and adhesion molecules secondarily to the activation of immune cells. Whether interactions via these molecules are obligatory in adjuvants' ability to potentiation vaccine immunogenicity is less clear. We investigated the ability of eight adjuvant formulations to potentiate the immunogenicity of a malaria vaccine in mice deficient in the prominent co-stimulatory molecules, CD80 and CD86; and the adhesion ligand, ICAM-1. While no adjuvants could bypass co-stimulatory requirements, more formulations exhibited dependency for CD86 than for CD80. In CD80 or CD86 KO mice, formulations with the saponin derivative, QS21 could efficiently default to the other B7 molecule. This effect was dominant over other adjuvant constituents. The requirement for ICAM-1 could be readily bypassed using adjuvant formulations containing immunomodulators; whereas this was not the case with emulsion-type adjuvants in which reduction in adjuvanticity was associated with decreases in antigen-specific IFN-gamma responses. These studies may help to guide the formulation of vaccine adjuvants to maintain effectiveness in hosts with altered immunological environment that often result from infections.
Authors:
George Hui; Caryn Hashimoto
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-10-26
Journal Detail:
Title:  Vaccine     Volume:  25     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-10     Completed Date:  2008-03-31     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  8549-56     Citation Subset:  IM    
Affiliation:
Department of Tropical Medicine and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, HI 96813, United States. ghui@hawaii.edu
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / administration & dosage,  pharmacology*
Animals
Antibodies, Protozoan / analysis,  biosynthesis*
Antigens, CD80 / immunology*
Antigens, CD86 / immunology*
Antigens, Protozoan / chemistry,  immunology
Chemistry, Pharmaceutical
Dose-Response Relationship, Immunologic
Enzyme-Linked Immunosorbent Assay
Female
Intercellular Adhesion Molecule-1 / immunology*
Interferon-gamma / blood
Interleukin-4 / blood
Malaria Vaccines / administration & dosage,  immunology*
Malaria, Falciparum / blood*,  prevention & control*
Merozoite Surface Protein 1 / immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Plasmodium falciparum / immunology*
Spleen / cytology,  drug effects,  metabolism
Grant Support
ID/Acronym/Agency:
K08 HD043279-05/HD/NICHD NIH HHS; R01 AI045768-01A1/AI/NIAID NIH HHS; R01 AI045768-02/AI/NIAID NIH HHS; R01 AI045768-03/AI/NIAID NIH HHS; R01 AI045768-04/AI/NIAID NIH HHS; R01AI45768/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antibodies, Protozoan; 0/Antigens, CD80; 0/Antigens, CD86; 0/Antigens, Protozoan; 0/Malaria Vaccines; 0/Merozoite Surface Protein 1; 126547-89-5/Intercellular Adhesion Molecule-1; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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