Document Detail

E(nos)/CG4699 required for nanos function in the female germ line of Drosophila.
MedLine Citation:
PMID:  20095054     Owner:  NLM     Status:  MEDLINE    
The translational repressor Nanos is required in the germ line stem cells of the Drosophila ovary to maintain their capacity for self-renewal. Following division of the stem cells, Nanos is inhibited in the daughters that differentiate into cysts and ultimately become mature oocytes. The control of Nanos activity is thus an important aspect of the switch from self-renewal to differentiation. In this report, we describe a genetic interaction between nanos and Enhancer of nos, an allele of the previously uncharacterized locus CG4699. We find that E(nos) protein is required for normal accumulation of Nanos in the ovary and thus for maintenance of the germ line. The mechanism by which E(nos)/CG4699 protein acts is not clear, although it has been found in a complex with Mof acetylase. Consistent with the finding that E(nos) interacts with Mof, we observe that nanos and mof also interact genetically to maintain normal oogenesis.
Lin Yu; Yan Song; Robin P Wharton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Genesis (New York, N.Y. : 2000)     Volume:  48     ISSN:  1526-968X     ISO Abbreviation:  Genesis     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100931242     Medline TA:  Genesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  161-70     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
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MeSH Terms
Animals, Genetically Modified
Base Sequence
Blotting, Western
Drosophila Proteins / genetics,  metabolism*
Drosophila melanogaster / cytology,  genetics,  metabolism*
Epistasis, Genetic
Green Fluorescent Proteins / genetics,  metabolism
Microscopy, Confocal
Ovary / cytology,  metabolism
Ovum / cytology,  metabolism*
RNA-Binding Proteins / genetics,  metabolism*
Recombinant Fusion Proteins / genetics,  metabolism
Reg. No./Substance:
0/CG4669 protein, Drosophila; 0/Drosophila Proteins; 0/RNA-Binding Proteins; 0/Recombinant Fusion Proteins; 142661-95-8/nanos protein, Drosophila; 147336-22-9/Green Fluorescent Proteins
Comment In:
Genesis. 2010 Mar;48(3):145   [PMID:  20213662 ]

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