| The reproductive outcome following a superhigh response to stimulation in gamete intrafallopian transfer program. | |
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MedLine Citation:
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PMID: 1753165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A retrospective analysis was carried out to assess the outcome of gamete intrafallopian transfer (GIFT) in cycles when more than 10 oocytes were retrieved (superhigh responders) from October 1987 through June 1989. There were 276 (13%) cycles with more than 10 oocytes retrieved among all GIFT cycles initiated during the period. Clomiphene citrate and gonadotropin were employed for ovarian stimulation in 105 (38%) cycles, and gonadotropin releasing hormone agonist in the remaining 171 (62%) cycles, employing either the flare (104 cycles) or the pituitary down-regulation (67 cycles) protocol. A maximum number of four oocytes was transferred per GIFT (3.5 +/- 0.4). The mean number of oocytes retrieved was 14.7 +/- 4.4 (range, 11 to 35). A significantly younger age group (less than 30 years) of patients was noticed in the study (31.9), and fewer women aged 40 and over (6.2%), compared to the general population of our patients. The pregnancy rate was 33.3% (n = 92) per cycle, with a delivery rate of 23.6% (n = 64) per cycle; the pregnancy loss rate was 30.8%. The reproductive outcome was lower in women aged 40 and over (pregnancy rate was 23.5%, but delivery rate was only 5.8% per cycle). The delivery rate was lower in the clomiphene citrate- and gonadotropin-stimulated cycles (51.7% per pregnancy) in relation to gonadotropin-releasing analogue and gonadotropin cycles (76.6% per pregnancy) and significantly so compared with the pituitary down-regulation protocol (83.3% per pregnancy). We conclude that a superhigh response develops more in younger women, and in such circumstances, the use of pituitary down-regulation with gonadotropin-releasing hormone will improve the reproductive outcome. |
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Authors:
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T al-Shawaf; A Nolan; P Nadkarni; J Harper; J Brown; R Guirgis; G Emerson; M Bayly; I Craft |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of in vitro fertilization and embryo transfer : IVF Volume: 8 ISSN: 0740-7769 ISO Abbreviation: J In Vitro Fert Embryo Transf Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1992-01-30 Completed Date: 1992-01-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8412594 Medline TA: J In Vitro Fert Embryo Transf Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 202-7 Citation Subset: IM |
Affiliation:
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London Fertility Centre, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Buserelin / therapeutic use Clomiphene / therapeutic use Embryo Transfer Female Gamete Intrafallopian Transfer* Humans Menotropins / therapeutic use Ovulation Induction / methods Pregnancy Pregnancy Outcome* Retrospective Studies Superovulation* |
| Chemical | |
Reg. No./Substance:
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57982-77-1/Buserelin; 61489-71-2/Menotropins; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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