| The reproducibility of the response of the human newborn to CO2 measured by rebreathing and steady-state methods. | |
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MedLine Citation:
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PMID: 8046649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ventilatory response (VR) of the full-term newborn to CO2 was studied during quiet sleep using rebreathing and steady-state methods. Rebreathing responses were obtained under normoxic (fractional inspired oxygen concentration, Fi,O2 = 0.21) and hyperoxic (Fi,O2 = 0.4) conditions. Ten infants were tested three to five times using each of the two rebreathing protocols and the results averaged. Overall, there was no significant difference between either the mean variability (coefficient of variation) or slope of the VR measured under normoxic and hyperoxic conditions. Four infants were studied using a steady-state technique. There was marked test-to-test variability in VRs measured by this method. The results appear to indicate that the variability of the VR of the newborn to CO2 is not a result of chemoreflex changes in ventilation elicited in response to fluctuations in arterial PO2. |
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Authors:
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G Cohen; D J Henderson-Smart |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of physiology Volume: 476 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-09-01 Completed Date: 1994-09-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 355-63 Citation Subset: IM |
Affiliation:
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Department of Perinatal Medicine, King George V Hospital, Camperdown, NSW, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Behavior
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drug effects Carbon Dioxide / metabolism, pharmacology* Electroencephalography / drug effects Electrooculography Female Humans Infant, Newborn / physiology* Male Oxygen / blood Pulmonary Gas Exchange / drug effects Respiratory Mechanics / drug effects Tidal Volume / physiology |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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