Document Detail

The reproducibility of the response of the human newborn to CO2 measured by rebreathing and steady-state methods.
MedLine Citation:
PMID:  8046649     Owner:  NLM     Status:  MEDLINE    
The ventilatory response (VR) of the full-term newborn to CO2 was studied during quiet sleep using rebreathing and steady-state methods. Rebreathing responses were obtained under normoxic (fractional inspired oxygen concentration, Fi,O2 = 0.21) and hyperoxic (Fi,O2 = 0.4) conditions. Ten infants were tested three to five times using each of the two rebreathing protocols and the results averaged. Overall, there was no significant difference between either the mean variability (coefficient of variation) or slope of the VR measured under normoxic and hyperoxic conditions. Four infants were studied using a steady-state technique. There was marked test-to-test variability in VRs measured by this method. The results appear to indicate that the variability of the VR of the newborn to CO2 is not a result of chemoreflex changes in ventilation elicited in response to fluctuations in arterial PO2.
G Cohen; D J Henderson-Smart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  476     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-01     Completed Date:  1994-09-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  355-63     Citation Subset:  IM    
Department of Perinatal Medicine, King George V Hospital, Camperdown, NSW, Australia.
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MeSH Terms
Behavior / drug effects
Carbon Dioxide / metabolism,  pharmacology*
Electroencephalography / drug effects
Infant, Newborn / physiology*
Oxygen / blood
Pulmonary Gas Exchange / drug effects
Respiratory Mechanics / drug effects
Tidal Volume / physiology
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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