| Is reporting of recurrence data important in pancreatic cancer? | |
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MedLine Citation:
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PMID: 14993026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Therapeutic approaches to patients with pancreatic cancer have undergone a paradigm shift in recent years. However, little is known about the outcome of patients with recurrent pancreatic cancer who undergo treatment. The purpose of this study was to identify patients with recurrent pancreatic cancer and to determine whether treatment after recurrence had any effect on outcome. METHODS: A review of all patients undergoing surgical resection with curative intent revealed 70 patients with documented recurrence and complete medical records. Patients were grouped into three categories: group 1 included those who received treatment after recurrence (n = 45), group 2 included those who were not offered treatment (n = 9), and group 3 included those with poor performance status who received no treatment (n = 16). RESULTS: The median overall survival for the three groups was 26, 18, and 14.5 months for groups 1, 2, and 3, respectively (P <.00001). The median survival after recurrence was 10 months, 6 months, and 1 month, respectively, for the three groups (P <.0001). CONCLUSIONS: This is the first series we are aware of that compares the outcomes of patients who received treatment after recurrence of pancreatic cancer with the outcomes of those who received no treatment. In this series, it seems that patients who were well enough to tolerate additional therapy had a longer survival than those who received supportive care only. This may be important in the analysis of adjuvant therapy trials of pancreatic cancer with survival as an end point. |
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Authors:
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Michael O Meyers; Ingrid M Meszoely; John P Hoffman; James C Watson; Eric Ross; Burton L Eisenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of surgical oncology Volume: 11 ISSN: 1068-9265 ISO Abbreviation: Ann. Surg. Oncol. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-02 Completed Date: 2004-06-01 Revised Date: 2007-07-18 |
Medline Journal Info:
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Nlm Unique ID: 9420840 Medline TA: Ann Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 304-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy,
pathology*,
surgery* Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols / therapeutic use Combined Modality Therapy Data Collection Databases, Factual Female Follow-Up Studies Humans Male Middle Aged Neoplasm Recurrence, Local / drug therapy, pathology*, surgery* Pancreatic Neoplasms / drug therapy, pathology*, surgery* Prognosis Survival Analysis Time Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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