Document Detail

A report of two cases of Kawasaki disease treated with plasma exchange.
MedLine Citation:
PMID:  18387169     Owner:  NLM     Status:  MEDLINE    
Kawasaki disease is a generalized vasculitis of unknown etiology that occurs predominantly in infants and young children. It is very important to prevent its cardiovascular manifestations, especially coronary artery lesions. Early treatment with intravenous immunoglobulin reduces cardiovascular sequelae, but some patients do not respond to this treatment, and they have a high incidence of coronary artery lesions. On the other hand, acute heart failure is rare in Kawasaki disease. We report on the cases of two patients with persistent fever and shock even after intravenous immunoglobulin therapy. In both cases, plasma exchange may have reduced the risk of coronary artery lesions and proved effective against acute heart failure with catecholamine-refractory shock; yet the mechanism of this improvement remains unclear.
Tomonori Harada; Shuichi Ito; Kentaro Shiga; Aya Inaba; Hiroyuki Machida; Yukoh Aihara; Shumpei Yokota
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  12     ISSN:  1744-9987     ISO Abbreviation:  Ther Apher Dial     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-05-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  176-9     Citation Subset:  IM    
Children's Medical Center, Yokohama City University Medical Center, Yokohama, Japan.
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MeSH Terms
Child, Preschool
Coronary Vessels / pathology
Heart Failure / etiology,  prevention & control*
Immunoglobulins, Intravenous / therapeutic use
Mucocutaneous Lymph Node Syndrome / complications,  physiopathology,  therapy*
Plasma Exchange*
Treatment Outcome
Reg. No./Substance:
0/Immunoglobulins, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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