Document Detail


The repertoires of circulating human CD8(+) central and effector memory T cell subsets are largely distinct.
MedLine Citation:
PMID:  12594947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Memory T cells are divided into central and effector subsets with distinct functions and homing capabilities. We analyzed the composition and dynamics of the CD8(+) T cell repertoire of these subsets within the peripheral blood of four healthy individuals. Both subsets had largely distinct and autonomous TCRbeta repertoires. Their composition remained stable over a 9 month period, during which no cell passage between these subsets was detected despite important size variation of several clones. In one donor, four out of six TCRbeta clonotypes specific for the influenza A virus were detected in the central subset only, while the two others were shared. Altogether, these observations suggest that most effector memory T cells may not have derived from the central memory subset.
Authors:
Véronique Baron; Cécile Bouneaud; Ana Cumano; Annick Lim; T Petteri Arstila; Philippe Kourilsky; Laurent Ferradini; Christophe Pannetier
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunity     Volume:  18     ISSN:  1074-7613     ISO Abbreviation:  Immunity     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-21     Completed Date:  2003-03-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9432918     Medline TA:  Immunity     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-204     Citation Subset:  IM    
Affiliation:
Unité de Biologie Moléculaire du Gène, INSERM U277, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD45 / metabolism
Base Sequence
CD8-Positive T-Lymphocytes / cytology,  immunology*
Cell Differentiation
DNA / genetics
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Humans
Immunologic Memory*
L-Selectin / metabolism
Middle Aged
Models, Immunological
T-Lymphocyte Subsets / cytology,  immunology*
Time Factors
Chemical
Reg. No./Substance:
126880-86-2/L-Selectin; 9007-49-2/DNA; EC 3.1.3.48/Antigens, CD45

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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