Document Detail


The repertoire of desaturases for unsaturated fatty acid synthesis in 397 genomes.
MedLine Citation:
PMID:  17503367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatty acids are the major components of membrane molecules. The fact that unsaturated fatty acids play multiple important roles, physically and biologically, means that the ratio of unsaturated to saturated fatty acids in the membrane needs to be strictly regulated to maintain cellular homeostasis. The most ubiquitous and widespread modification to fatty acids, which results in a great diversity of different structures, is the insertion of double bonds. Fatty acid desaturases directly introduce regioselective double bonds into fatty acids. A phylogenetic analysis of desaturases suggests that the sequences of these proteins include a highly conserved domain, which determines the differences in specificity and regioselectivity found in these enzymes. In this study, we performed a systematic analysis of fatty acid desaturases found in the genomic data of 397 organisms. We obtained a set of desaturases clustered by regioselectivity using a hierarchal clustering analysis.
Authors:
Kosuke Hashimoto; Akiyasu C Yoshizawa; Koichi Saito; Takuji Yamada; Minoru Kanehisa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genome informatics. International Conference on Genome Informatics     Volume:  17     ISSN:  0919-9454     ISO Abbreviation:  -     Publication Date:  2006  
Date Detail:
Created Date:  2007-05-15     Completed Date:  2007-07-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101280573     Medline TA:  Genome Inform     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  173-83     Citation Subset:  IM    
Affiliation:
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. khashimo@kuicr.kyoto-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Archaeal Proteins / biosynthesis,  genetics,  physiology
Bacterial Proteins / biosynthesis,  genetics,  physiology
Fatty Acid Desaturases / classification,  genetics*,  physiology
Fatty Acids, Unsaturated / biosynthesis*,  classification,  genetics
Genomics*
Humans
Oryza sativa / genetics
Plant Proteins / biosynthesis,  genetics,  physiology
Sequence Homology
Chemical
Reg. No./Substance:
0/Archaeal Proteins; 0/Bacterial Proteins; 0/Fatty Acids, Unsaturated; 0/Plant Proteins; EC 1.14.19.-/Fatty Acid Desaturases

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