Document Detail

The repertoire of desaturases for unsaturated fatty acid synthesis in 397 genomes.
MedLine Citation:
PMID:  17503367     Owner:  NLM     Status:  MEDLINE    
Fatty acids are the major components of membrane molecules. The fact that unsaturated fatty acids play multiple important roles, physically and biologically, means that the ratio of unsaturated to saturated fatty acids in the membrane needs to be strictly regulated to maintain cellular homeostasis. The most ubiquitous and widespread modification to fatty acids, which results in a great diversity of different structures, is the insertion of double bonds. Fatty acid desaturases directly introduce regioselective double bonds into fatty acids. A phylogenetic analysis of desaturases suggests that the sequences of these proteins include a highly conserved domain, which determines the differences in specificity and regioselectivity found in these enzymes. In this study, we performed a systematic analysis of fatty acid desaturases found in the genomic data of 397 organisms. We obtained a set of desaturases clustered by regioselectivity using a hierarchal clustering analysis.
Kosuke Hashimoto; Akiyasu C Yoshizawa; Koichi Saito; Takuji Yamada; Minoru Kanehisa
Related Documents :
17503367 - The repertoire of desaturases for unsaturated fatty acid synthesis in 397 genomes.
2196087 - Cell-free synthesis of mycolic acids in mycobacterium aurum: radioactivity distribution...
3665357 - Increased arachidonic acid levels in phospholipids of human colonic mucosa in inflammat...
9392507 - Thiazolidinediones downregulate stearoyl-coa desaturase 1 gene expression in 3t3-l1 adi...
18965217 - Ascorbic acid as a matrix modifier for determination of tin in concentrated boric acid ...
17723457 - Preventing inhibition of tyrosinase with modified electrodes.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genome informatics. International Conference on Genome Informatics     Volume:  17     ISSN:  0919-9454     ISO Abbreviation:  -     Publication Date:  2006  
Date Detail:
Created Date:  2007-05-15     Completed Date:  2007-07-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101280573     Medline TA:  Genome Inform     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  173-83     Citation Subset:  IM    
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Archaeal Proteins / biosynthesis,  genetics,  physiology
Bacterial Proteins / biosynthesis,  genetics,  physiology
Fatty Acid Desaturases / classification,  genetics*,  physiology
Fatty Acids, Unsaturated / biosynthesis*,  classification,  genetics
Oryza sativa / genetics
Plant Proteins / biosynthesis,  genetics,  physiology
Sequence Homology
Reg. No./Substance:
0/Archaeal Proteins; 0/Bacterial Proteins; 0/Fatty Acids, Unsaturated; 0/Plant Proteins; EC 1.14.19.-/Fatty Acid Desaturases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Structural analysis of expressed metabolic subnetworks.
Next Document:  Metabolite antigens and pathway incompatibility.