| The repertoire of desaturases and elongases reveals fatty acid variations in 56 eukaryotic genomes. | |
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MedLine Citation:
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PMID: 17921532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The repertoire of biosynthetic enzymes found in an organism is an important clue for elucidating the chemical structural variations of various compounds. In the case of fatty acids, it is essential to examine key enzymes that are desaturases and elongases, whose combination determine the range of fatty acid structures. We systematically investigated 56 eukaryotic genomes to obtain 275 desaturase and 265 elongase homologs. Phylogenetic and motif analysis indicated that the desaturases consisted of four functionally distinct subfamilies and the elongases consisted of two subfamilies. From the combination of the subfamilies, we then predicted the ability to synthesize six types of fatty acids. Consequently, we found that the ranges of synthesizable fatty acids were often different even between closely related organisms. The reason is that, as well as diverging into subfamilies, the enzymes have functionally diverged within the individual subfamilies. Finally, we discuss how the adaptation to individual environments and the ability to synthesize specific metabolites provides some explanation for the diversity of enzyme functions. This study provides an example of a potent strategy to bridge the gap from genomic knowledge to chemical knowledge. |
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Authors:
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Kosuke Hashimoto; Akiyasu C Yoshizawa; Shujiro Okuda; Keiichi Kuma; Susumu Goto; Minoru Kanehisa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-07 |
Journal Detail:
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Title: Journal of lipid research Volume: 49 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-26 Completed Date: 2008-03-07 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
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Languages: eng Pagination: 183-91 Citation Subset: IM |
Affiliation:
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Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetyltransferases
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chemistry*,
classification,
genetics,
metabolism Amino Acid Sequence Animals Base Sequence Evolution, Molecular Fatty Acid Desaturases / chemistry*, classification, genetics, metabolism Fatty Acids, Unsaturated / biosynthesis*, chemistry Fungi / enzymology Genome Humans Molecular Sequence Data Phylogeny Plants / enzymology |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; EC 1.14.19.-/Fatty Acid Desaturases; EC 2.3.1.-/Acetyltransferases; EC 2.3.1.-/fatty acid elongases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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