Document Detail


The repair of the injured adult rat hippocampus with NT-3-chitosan carriers.
MedLine Citation:
PMID:  20022104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The injury of the CA1 region of the adult rat hippocampus causes cognitive impairment. In this study, animal models were established by mechanically injuring the CA1 region of the adult rat hippocampus, and into the injured area were implanted chitosan carriers loaded either with or without NT-3. Immunohistochemical and nerve tracer methods were adopted to observe the role of the above-mentioned carriers in repairing the injured brain and to observe the scar formation after the injury, and Morris water maze (MWM) tests were performed to evaluate the recovery degree of the cognitive function. The results showed that NT-3-chitosan carriers stimulated regeneration of a large amount of NF-positive nerve fiber and neuron-like cells into the injured area. The newly regenerated NF-positive nerve fibers in the injured area rebuilt a neural circuit with the contralateral CA1 region via corpus callosum. Comparison of the lesion control rats and the treated rats indicates that the chitosan carriers loaded either with or without NT-3 may significantly improve the cognitive function after the hippocampus injury.
Authors:
Linhong Mo; Zhaoyang Yang; Aifeng Zhang; Xiaoguang Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-21
Journal Detail:
Title:  Biomaterials     Volume:  31     ISSN:  1878-5905     ISO Abbreviation:  Biomaterials     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  2184-92     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Beijing Institute for Neuroscience, Capital Medical University, and Beijing Friendship Hospital, Beijing 100069, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials / chemistry,  metabolism
Chitosan / chemistry,  metabolism*
Cognition / physiology
Drug Carriers / chemistry,  metabolism*
Hippocampus / anatomy & histology,  metabolism*,  pathology
Materials Testing
Maze Learning / physiology
Nerve Regeneration / physiology*
Neurotrophin 3 / chemistry,  metabolism*
Rats
Rats, Wistar
Recovery of Function / physiology
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Drug Carriers; 0/Neurotrophin 3; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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