| The reorganization and reactivation of hippocampal maps predict spatial memory performance. | |
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MedLine Citation:
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PMID: 20639874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hippocampus is an important brain circuit for spatial memory and the spatially selective spiking of hippocampal neuronal assemblies is thought to provide a mnemonic representation of space. We found that remembering newly learnt goal locations required NMDA receptor-dependent stabilization and enhanced reactivation of goal-related hippocampal assemblies. During spatial learning, place-related firing patterns in the CA1, but not CA3, region of the rat hippocampus were reorganized to represent new goal locations. Such reorganization did not occur when goals were marked by visual cues. The stabilization and successful retrieval of these newly acquired CA1 representations of behaviorally relevant places was NMDAR dependent and necessary for subsequent memory retention performance. Goal-related assembly patterns associated with sharp wave/ripple network oscillations, during both learning and subsequent rest periods, predicted memory performance. Together, these results suggest that the reorganization and reactivation of assembly firing patterns in the hippocampus represent the formation and expression of new spatial memory traces. |
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Authors:
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David Dupret; Joseph O'Neill; Barty Pleydell-Bouverie; Jozsef Csicsvari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-18 |
Journal Detail:
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Title: Nature neuroscience Volume: 13 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-08-20 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 995-1002 Citation Subset: IM |
Affiliation:
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MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford, UK. david.dupret@pharm.ox.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Mapping Electrodes, Implanted Hippocampus / physiology* Male Memory / physiology* Rats Rats, Long-Evans Space Perception / physiology* Spatial Behavior / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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U.1381.00.004.00001.01(69944)//Medical Research Council; //Medical Research Council |
| Comments/Corrections | |
Comment In:
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Nat Neurosci. 2010 Aug;13(8):911-2
[PMID:
20661265
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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