| The renin phenotype: roles and regulation in the kidney. | |
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MedLine Citation:
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PMID: 20502328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Renin cells are fundamental for the control of blood pressure, fluid electrolyte homeostasis and kidney development. This review discusses recent discoveries regarding the mechanisms that control the identity and fate of renin cells and their role in the maintenance of kidney architecture and function. RECENT FINDINGS: It is now established that cyclic AMP is a crucial factor for the regulation of the renin phenotype. Furthermore, additional factors such as microRNAs and gap junctions have recently emerged as key regulators for the maintenance and proper functioning of renin cells. SUMMARY: Experiments described in this review will hopefully raise new questions regarding the mechanisms that control the identity, plasticity and function of renin cells. |
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Authors:
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Maria L S Sequeira Lopez; R Ariel Gomez |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current opinion in nephrology and hypertension Volume: 19 ISSN: 1535-3842 ISO Abbreviation: Curr. Opin. Nephrol. Hypertens. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-10-19 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9303753 Medline TA: Curr Opin Nephrol Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 366-71 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Connexins / metabolism Gap Junctions / metabolism Humans Kidney / cytology, physiology* MicroRNAs / metabolism Phenotype Renin / metabolism, physiology* Transcription Factors |
| Grant Support | |
ID/Acronym/Agency:
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DK75481/DK/NIDDK NIH HHS; HL066242/HL/NHLBI NIH HHS; K08 DK075481-01/DK/NIDDK NIH HHS; K08 DK075481-02/DK/NIDDK NIH HHS; K08 DK075481-03/DK/NIDDK NIH HHS; K08 DK075481-04/DK/NIDDK NIH HHS; K08 DK075481-04S1/DK/NIDDK NIH HHS; K08 DK075481-05/DK/NIDDK NIH HHS; R37 HL066242-06/HL/NHLBI NIH HHS; R37 HL066242-07/HL/NHLBI NIH HHS; R37 HL066242-08/HL/NHLBI NIH HHS; R37 HL066242-08S1/HL/NHLBI NIH HHS; R37 HL066242-09/HL/NHLBI NIH HHS; R37 HL066242-10/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Connexins; 0/MicroRNAs; 0/Transcription Factors; EC 3.4.23.15/Renin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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