Document Detail

The renin-angiotensin system and the pathogenesis of vascular disease in malignant hypertension.
MedLine Citation:
PMID:  1071605     Owner:  NLM     Status:  MEDLINE    
1. The syndrome of malignant hypertension in man and animals has three fundamental components: high blood pressure, activation of the renin-angiotensin system and the rapid development of necrotizing arteriolar disease. 2. The high blood pressure can be associated with different conformations of the arteriolar microcirculation. The emergence of an arteriolar reaction pattern characterized by the formation of focal dilatations, with intervening constricted segments, is of fundamental pathophysiological importance. 3. Activation of the renin system is reflected in an increased renin secretion rate from the kidneys and an increased rate of angiotensin II generation in the pulmonary vascular bed. 4. The crucial pathogenetic process, leading eventually to severe arteriolar wall damage, is a penetration of plasmatic macromolecules into the wall of distended arteriolar segments, as observed in states of severe experimental hypertension. 5. Renin can induce vascular disease, but hypersecretion of renin is not a necessary condition for the development of hypertensive arteriolar necrosis.
J Geise
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine. Supplement     Volume:  3     ISSN:  0144-4107     ISO Abbreviation:  Clin Sci Mol Med Suppl     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  7907311     Medline TA:  Clin Sci Mol Med Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  19s-21s     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / secretion*
Hypertension, Malignant / complications*,  physiopathology
Kidney / secretion
Renin / secretion*
Secretory Rate
Vascular Diseases / etiology*
Reg. No./Substance:
11128-99-7/Angiotensin II; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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