| The renin-angiotensin system: a link between obesity, inflammation and insulin resistance. | |
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MedLine Citation:
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PMID: 22034852 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The renin-angiotensin system (RAS) is classically known for its role in regulation of blood pressure, fluid and electrolyte balance. Recently, several local RASs in organs such as brain, heart, pancreas and adipose tissue have also been identified. Evidence from clinical trials suggests that in addition to anti-hypertensive effects, pharmacological inhibition of RAS also provides protection against the development of type-2 diabetes. Moreover, animal models with targeted inactivation of RAS genes exhibit improved insulin sensitivity and are protected from high-fat diet-induced obesity and insulin resistance. Because there is evidence for RAS overactivation in obesity, it is possible that RAS is a link between obesity and insulin resistance. This review summarizes the evidence and mechanistic insights on the associations between RAS, obesity and insulin resistance, with special emphasis on the role of adipose tissue RAS in the pathogenesis of metabolic derangements in obesity. |
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Authors:
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N S Kalupahana; N Moustaid-Moussa |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-31 |
Journal Detail:
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Title: Obesity reviews : an official journal of the International Association for the Study of Obesity Volume: - ISSN: 1467-789X ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897395 Medline TA: Obes Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. obesity reviews © 2011 International Association for the Study of Obesity. |
Affiliation:
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Obesity Research Center Department of Animal Science UT Extension Family and Consumer Sciences Department, The University of Tennessee (UT), Knoxville, TN, USA Department of Physiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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