Document Detail

The renin-angiotensin system and hypertensive left ventricular hypertrophy in the rat.
MedLine Citation:
PMID:  6240358     Owner:  NLM     Status:  MEDLINE    
The relationship between left ventricle-to-body weight ratio (LV/BW), mean arterial pressure (MAP, the average of 12 h of intra-arterial monitoring in conscious animals) and plasma renin activity (PRA) was assessed at 12 weeks after unilateral clipping or sham operation in twenty-four one-kidney rats and twenty-six two-kidney rats. The degree of hypertension and left ventricular hypertrophy were similar in one-kidney and two-kidney groups. There was a close linear relationship between LV/BW and MAP which was similar in one-kidney and two-kidney rats. PRA was significantly elevated only in two-kidney rats and was not related to the degree of hypertrophy after accounting for the effect of PRA on MAP. These data suggest that activation of the renin-angiotensin system does not contribute directly to myocardial hypertrophy in rats with renal-clip hypertension.
R Newling; P J Fletcher; G G Duggin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  11     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1985-03-07     Completed Date:  1985-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  419-22     Citation Subset:  IM    
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MeSH Terms
Body Weight
Cardiomegaly / etiology*
Hypertension / complications,  physiopathology*
Rats, Inbred Strains
Renin-Angiotensin System*

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