Document Detail

The renin-aldosterone system in dihydralazine therapy during hypertensive pregnancy.
MedLine Citation:
PMID:  365799     Owner:  NLM     Status:  MEDLINE    
Ten patients with hypertensive pregnancy were studied in hospital for 3 weeks. Plasma renin activity (PRA), the daily urinary excretion of aldosterone (dU-Aldo) and electrolytes were studied before and during dihydralazine therapy (25 mg 3 times daily). In one week the supine blood pressure decreased (p less than 0.05) without any discernible tachycardia. PRA increased in 3 days of the treatment by 50% (p less than 0.05) and this mean level was maintained. In dU-Aldo no change was found, however, during the study; and the excretions of sodium and potassium remained unchanged as well. In patients without diuretic therapy the basal PRA level before dihydralazine therapy was lower than in normal pregnancy. Also, in patients with preceding diuretic therapy the basal level of PRA was lower than during diuretics in gravidas without hypertension. Judging from the animal experiments, the rise in PRA might be seen as favorable for uteroplacental circulation in pregnancy hypertension.
R Lammintausta
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology and biopharmacy     Volume:  16     ISSN:  0340-0026     ISO Abbreviation:  Int J Clin Pharmacol Biopharm     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7505527     Medline TA:  Int J Clin Pharmacol Biopharm     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  581-4     Citation Subset:  IM    
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MeSH Terms
Aldosterone / urine*
Blood Pressure / drug effects
Clinical Trials as Topic
Dihydralazine / pharmacology*,  therapeutic use
Electrolytes / urine
Heart Rate / drug effects
Hydralazine / analogs & derivatives*
Hypertension / drug therapy*,  metabolism
Pregnancy Complications, Cardiovascular / drug therapy*,  metabolism
Renin / blood*
Time Factors
Reg. No./Substance:
0/Electrolytes; 484-23-1/Dihydralazine; 52-39-1/Aldosterone; 86-54-4/Hydralazine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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