Document Detail

The renal stem cell system in kidney repair and regeneration.
MedLine Citation:
PMID:  18508667     Owner:  NLM     Status:  MEDLINE    
The adult mammalian renal tubular epithelium exists in a relatively quiescent to slowly replicating state, but has great potential for regenerative morphogenesis following severe ischemic or toxic injury. Kidney regeneration and repair occur through three cellular and molecular mechanisms: differentiation of the somatic stem cells, recruitment of circulating stem cells and, more importantly, proliferation/dedifferentiation of mature cells. Dedifferentiation seems to represent a critical step for the recovery of tubular integrity. Dedifferentiation of tubular cells after injury is characterized by the reactivation of a mesenchymal program that is active during nephrogenesis. Epithelial-to-mesenchymal transition (EMT) of renal tubular cells is an extreme manifestation of epithelial cell plasticity. It is now widely recognized as a fundamental process that marks some physiological, such as morphogenesis, as well as pathological events, such as oncogenesis and fibrogenesis. It might be also considered as a key event in the regenerative process of the kidney. Understanding the molecular mechanisms involved in EMT might be useful for designing therapeutic strategies in order to potentiate the innate capacity of the kidney to regenerate.
Franca Anglani; Monica Ceol; Federica Mezzabotta; Rossella Torregrossa; Emilia Tiralongo; Enrica Tosetto; Dorella Del Prete; Angela D'Angelo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  13     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6395-405     Citation Subset:  IM    
Kidney Histomorphology and Molecular Biology Laboratory, Department of Medical and Surgical Sciences, University of Padua, Italy.
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MeSH Terms
Bone Marrow Cells / cytology,  physiology
Cell Differentiation
Epithelial Cells / cytology,  physiology
Ischemia / physiopathology
Kidney / cytology,  injuries,  physiology*,  physiopathology
Kidney Tubules / cytology,  physiology
Reference Values
Regeneration / physiology*
Renal Circulation / physiology
Stem Cells / cytology,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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