| The renal physiology of pendrin (SLC26A4) and its role in hypertension. | |
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MedLine Citation:
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PMID: 17120771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SLC26A4 (pendrin, PDS) is a Na+-independent, Cl-/HCO3-/OH- exchanger that is expressed in the apical regions of type B and non-A, non-B intercalated cells within the cortical collecting duct (CCD), the connecting tubule and the distal convoluted tubule where it mediates HCO3- secretion and Cl- absorption. SLC26A4 is upregulated with aldosterone analogues and with Cl- restriction. While under basal conditions no renal abnormalities are observed in mice and humans with genetic disruption of SLC26A4 (Pendred syndrome), differences become apparent under conditions wherein the transporter is stimulated. Following treatment with aldosterone analogues, e.g. deoxycorticosterone pivalate (DOCP), weight gain and hypertension are observed in Slc26a4+/+ but not in Slc26a4-/- mice. During dietary NaCl restriction, a model in which serum aldosterone is appropriately increased, urinary volume and urinary excretion of Cl- are greater in Slc26a4-/- than in wild-type mice which results in apparent vascular volume contraction in Slc26a4-/- mice. Moreover, during NaCl restriction or following DOCP treatment, Slc26a4-/- mice have a higher serum HCO3- than wild type mice from an impaired ability to excrete OH- equivalents. In conclusion, SLC26A4 regulates blood pressure and arterial pH, likely by participating in the renal regulation of net acid and Cl- excretion. |
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Authors:
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Susan M Wall |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Novartis Foundation symposium Volume: 273 ISSN: 1528-2511 ISO Abbreviation: Novartis Found. Symp. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-11-22 Completed Date: 2007-02-12 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9807767 Medline TA: Novartis Found Symp Country: England |
Other Details:
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Languages: eng Pagination: 231-9; discussion 239-43, 261-4 Citation Subset: IM |
Affiliation:
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Renal Division, Emory University School of Medicine, 1639 Pierce Drive, NE Atlanta, GA 30322, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorption
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drug effects Acid-Base Equilibrium / drug effects Aldosterone / analogs & derivatives Animals Anion Transport Proteins / metabolism* Bicarbonates / metabolism Blood Pressure / drug effects Body Weight / drug effects Chlorides / metabolism Cloning, Molecular Hypertension / metabolism*, physiopathology Kidney / physiology* Mice Sodium Chloride / pharmacology Systole / drug effects Up-Regulation / drug effects Water-Electrolyte Balance / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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DK 52935/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anion Transport Proteins; 0/Bicarbonates; 0/Chlorides; 0/Slc26a4 protein, mouse; 52-39-1/Aldosterone; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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