| The renaissance of corticotropin therapy in proteinuric nephropathies. | |
| | |
MedLine Citation:
|
PMID: 22143333 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Refractory nephrotic syndrome continues to be a therapeutic challenge despite advances in immunosuppression and blockade of the renin-angiotensin-aldosterone cascade. Adrenocorticotropic hormone (ACTH), a pituitary neuroimmunoendocrine polypeptide, was widely used in the 1950s as an effective therapy for childhood nephrotic syndrome, but has since been replaced by synthetic glucocorticoid analogues. In addition to controlling steroidogenesis, ACTH also acts as an important physiological agonist of the melanocortin system. Clinical and experimental evidence now suggests that ACTH has antiproteinuric, lipid-lowering and renoprotective properties, which are not fully explained by its steroidogenic effects. ACTH therapy is effective in inducing remission of nephrotic syndrome in patients with a variety of proteinuric nephropathies, even those resistant to steroids and other immunosuppressants. This Perspectives article describes the biophysiology of ACTH, with an emphasis on its melanocortin actions, particularly in renal parenchymal cells, which could potentially explain the therapeutic effects of ACTH in nephrotic glomerulopathies. |
| | |
Authors:
|
Rujun Gong |
Related Documents
:
|
21353143 - Potentiating effect of fluphenazine decanoate and risperidone on development of neurole... 21248883 - Neuroleptic malignant syndrome in an octogenarian: a case report. 7718973 - Boucher-neuhauser syndrome associated with hypocalciuric hypercalcemia. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-06 |
Journal Detail:
|
Title: Nature reviews. Nephrology Volume: - ISSN: 1759-507X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101500081 Medline TA: Nat Rev Nephrol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA. rujun_gong@brown.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genome-wide association studies of chronic kidney disease: what have we learned?
Next Document: Visible light driven hydrogen production from a photo-active cathode based on a molecular catalyst a...