Document Detail


The remodeling of connexin in the hypertrophied right ventricular in pulmonary arterial hypertension and the effect of a dual ET receptor antagonist (bosentan).
MedLine Citation:
PMID:  19232841     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies on the role of connexins (Cxs) in the pathogenesis of right ventricular (RV) hypertrophy in pulmonary arterial hypertension (PAH) have not been reported to date. Therefore, we established a rat model of PAH induced by monocrotaline (MCT), and they were randomized to three groups: Control, MCT, and MCT+bosentan. Through electromicroscopy, in the control group, the gap junctions were long and frequent in intercalated disks, and short and rare at the sites of side-side cell junctions. In the MCT group, the opposite distribution was detected. In the MCT+bosentan group, the distribution of gap junctions was similar to that in the control group. Using immunoconfocal microscopy, most of the Cx43 staining was aggregated at the cell termini, and staining was weak at the sites of side-side cell junctions in the control group. However, the distribution of Cx43 was opposite in the MCT group. In the MCT+bosentan group, the result was similar to that in the control group. Therefore, perturbation of connexin distribution may be associated with RV hypertrophy. Improving the distribution of Cx43 in RV myocardium may be one of the mechanisms of a dual ET receptor antagonist partly reversing the RV hypertrophy.
Authors:
Xiao-Yan Tan; Jian-Guo He
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-20
Journal Detail:
Title:  Pathology, research and practice     Volume:  205     ISSN:  1618-0631     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-05     Completed Date:  2009-08-25     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  473-82     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, PR China. youxiang_2003@yahoo.com.cn
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MeSH Terms
Descriptor/Qualifier:
Animals
Connexin 43 / metabolism*
Disease Models, Animal
Gap Junctions / drug effects,  metabolism
Hemodynamics / drug effects
Hypertension, Pulmonary / chemically induced,  complications,  drug therapy*,  metabolism,  physiopathology
Hypertrophy, Right Ventricular / etiology,  metabolism,  physiopathology,  prevention & control*
Male
Microscopy, Confocal
Microscopy, Electron
Monocrotaline
Myocytes, Cardiac / drug effects*,  metabolism,  ultrastructure
Rats
Rats, Sprague-Dawley
Receptors, Endothelin / antagonists & inhibitors*
Sulfonamides / pharmacology*
Ventricular Remodeling / drug effects*
Chemical
Reg. No./Substance:
0/Connexin 43; 0/Receptors, Endothelin; 0/Sulfonamides; 315-22-0/Monocrotaline; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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