| The remodeling of connexin in the hypertrophied right ventricular in pulmonary arterial hypertension and the effect of a dual ET receptor antagonist (bosentan). | |
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MedLine Citation:
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PMID: 19232841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies on the role of connexins (Cxs) in the pathogenesis of right ventricular (RV) hypertrophy in pulmonary arterial hypertension (PAH) have not been reported to date. Therefore, we established a rat model of PAH induced by monocrotaline (MCT), and they were randomized to three groups: Control, MCT, and MCT+bosentan. Through electromicroscopy, in the control group, the gap junctions were long and frequent in intercalated disks, and short and rare at the sites of side-side cell junctions. In the MCT group, the opposite distribution was detected. In the MCT+bosentan group, the distribution of gap junctions was similar to that in the control group. Using immunoconfocal microscopy, most of the Cx43 staining was aggregated at the cell termini, and staining was weak at the sites of side-side cell junctions in the control group. However, the distribution of Cx43 was opposite in the MCT group. In the MCT+bosentan group, the result was similar to that in the control group. Therefore, perturbation of connexin distribution may be associated with RV hypertrophy. Improving the distribution of Cx43 in RV myocardium may be one of the mechanisms of a dual ET receptor antagonist partly reversing the RV hypertrophy. |
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Authors:
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Xiao-Yan Tan; Jian-Guo He |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-20 |
Journal Detail:
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Title: Pathology, research and practice Volume: 205 ISSN: 1618-0631 ISO Abbreviation: Pathol. Res. Pract. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-06-05 Completed Date: 2009-08-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806109 Medline TA: Pathol Res Pract Country: Germany |
Other Details:
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Languages: eng Pagination: 473-82 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, PR China. youxiang_2003@yahoo.com.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Connexin 43 / metabolism* Disease Models, Animal Gap Junctions / drug effects, metabolism Hemodynamics / drug effects Hypertension, Pulmonary / chemically induced, complications, drug therapy*, metabolism, physiopathology Hypertrophy, Right Ventricular / etiology, metabolism, physiopathology, prevention & control* Male Microscopy, Confocal Microscopy, Electron Monocrotaline Myocytes, Cardiac / drug effects*, metabolism, ultrastructure Rats Rats, Sprague-Dawley Receptors, Endothelin / antagonists & inhibitors* Sulfonamides / pharmacology* Ventricular Remodeling / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43; 0/Receptors, Endothelin; 0/Sulfonamides; 147536-97-8/bosentan; 315-22-0/Monocrotaline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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