| A reliable and valid protocol for measuring maximal oxygen uptake in pigs. | |
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MedLine Citation:
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PMID: 19543093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Most knowledge about cellular and molecular adaptation in the heart after exercise training comes from rodent models, and this has substantially improved our knowledge about exercise-induced cardiac adaptations. However, in rodents, the electrophysiological properties of the heart are different from the human heart. Therefore, the need of exercise-training models in larger animal models is obvious. Physiological studies of cardio-respiratory fitness require training regimens that give robust and adequate testing procedures to quantify the outcome. METHODS: We developed a valid and reproducible protocol for measuring maximal oxygen uptake (VO2max) in young pigs. As previous studies have exercised pigs using horizontal treadmills, we determined whether treadmill inclination may influence the level of peak oxygen uptake (VO2peak) achieved, and whether the true VO2max was reached. Eight young pigs were used. Submaximal and VO2peak were tested at five different inclinations from 13 to 30 degrees . RESULTS: At submaximal VO2, there was an excellent test-retest at all treadmill inclinations (r = 0.99, coefficient of variation = 1.8%). The level of VO2peak was dependent upon treadmill inclination and the true VO2max, defined as a levelling-off of VO2 despite increased running speed, was only reached a treadmill inclination of 24 degrees . For VO2peak we only observed a significant test-retest correlation when using 19 and 24 degrees inclination of the treadmill (r = 0.88, coefficient of variation = 9.7%). CONCLUSION: The use of inappropriate treadmill inclination might hide training-induced adaptations if the true VO2max is not reached. This study shows that the present test protocol can be used in future studies of exercise on treadmill, when the aim is to measure submaximal and VO2max in pigs. |
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Authors:
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Arve J?rgensen; Vegard J Berge; Alf O Brubakk; Ulrik Wisl?ff |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 16 ISSN: 1741-8275 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-01-06 Completed Date: 2010-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 628-32 Citation Subset: IM |
Affiliation:
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Department of Circulation and Medical Imaging, Faculty of Medicine, NTNU, Trondheim, Norway. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Exercise Test* Exercise Tolerance* Female Male Models, Animal Muscle, Skeletal / metabolism* Oxygen Consumption* Physical Exertion* Reproducibility of Results Swine |
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