| The relevance of urodynamic studies for Urge syndrome and dysfunctional voiding: a multicenter controlled trial in children. | |
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MedLine Citation:
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PMID: 18710726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The objective of this study was to compare prospectively, in urge syndrome and dysfunctional voiding, clinical patterns with urodynamic patterns, to assess changes in urodynamic patterns after treatment, and to correlate urodynamic patterns and parameters with treatment outcome. MATERIALS AND METHODS: In the European Bladder Dysfunction Study 97 children with clinically diagnosed urge syndrome received standard treatment, to which was randomly added placebo, oxybutynin or bladder training with online feedback. In a separate branch 105 children with clinically diagnosed dysfunctional voiding were randomly allocated to standard treatment or standard treatment plus pelvic floor training with online feedback. In all children urodynamic studies were performed before and immediately after treatment. RESULTS: In urge syndrome detrusor overactivity was present in 33% of cases before and 27% after treatment (of which 65% were de novo). Detrusor overactivity did not correlate with treatment outcome. In dysfunctional voiding increased pelvic floor activity during voiding, which was present in 67% of cases before and 56% after treatment (of which 45% were de novo), did not correlate with treatment outcome. In urge syndrome as well as in dysfunctional voiding neither maximum detrusor pressure during voiding, cystometric bladder capacity, bladder compliance nor free flow patterns correlated with treatment outcome. CONCLUSIONS: Neither detrusor overactivity nor increased pelvic floor activity during voiding correlated with treatment outcome. Standard treatment could be the first choice in urge syndrome as well as in dysfunctional voiding, reserving urodynamic studies for patients in whom this first approach fails. |
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Authors:
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An Bael; Hildegard Lax; Tom P V M de Jong; Piet Hoebeke; Rien J M Nijman; Rune Sixt; John Verhulst; Herbert Hirche; Jan D van Gool; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-08-16 |
Journal Detail:
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Title: The Journal of urology Volume: 180 ISSN: 1527-3792 ISO Abbreviation: J. Urol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-12 Completed Date: 2008-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
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Languages: eng Pagination: 1486-93; discussion 1494-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Antwerp University Hospital, Antwerp, Belgium. anbael@attglobal.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Chi-Square Distribution Child Electromyography Female Follow-Up Studies Humans Male Mandelic Acids / therapeutic use* Pelvic Floor / physiopathology Physical Examination Physical Therapy Modalities Probability Prospective Studies Risk Assessment Severity of Illness Index Sex Factors Statistics, Nonparametric Treatment Outcome Urinary Bladder, Overactive / diagnosis*, therapy* Urinary Incontinence, Urge / diagnosis*, therapy* Urodynamics* |
| Chemical | |
Reg. No./Substance:
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0/Mandelic Acids; 5633-20-5/oxybutynin |
| Investigator | |
Investigator/Affiliation:
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J Vande Walle / ; P Hoebeke / ; E Van Hoecke / ; K Renson / ; H De Paepe / ; A M Bael / ; H Olbing / ; T Tamminen-Möbius / ; E Gäbel / ; B Lettgen / ; M Bald / ; H Rübben / ; H Bachmann / ; K Heilenkötter / ; E Janhsen / ; J Misselwitz / ; U John / ; S Güntek / ; J Schubert / ; J D van Gool / ; T P V M de Jong / ; P Dik / ; P Winkler-Seinstra / ; G Knopper-Stolker / ; E de Bruyn / ; M Vijverberg / ; J Verhulst / ; J M Nijman / ; R van Zon / ; M Vlasblom / ; R van Mastrigt / ; K Hjälmås / ; U Jodal / ; A L Hellström / ; E Sölsnes / ; G Hermansson / ; R Sixt / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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