Document Detail


The relevance of molecular markers in the analysis of malaria parasite populations.
MedLine Citation:
PMID:  18666966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Malaria is one of the main human public health problems in the tropical world and is possibly becoming an emerging disease too in regions where it has been controlled. It has been an excellent model in the area of molecular studies, with scientific validation of techniques, application of data mainly in studies of parasite diversity and information on a number of different aspects associated with infection and disease. The transfer of the gathered knowledge and experience in malaria to other infections is of great use and we briefly review a number of molecular markers, methodologies and techniques mostly used for Plasmodium detection, as well as identification or characterization of parasite populations. Selection of appropriate techniques depends on the questions raised and the studies' objectives--the antigen-coding genes, microsatellite loci and drug-resistance associated markers being the three most analysed classes of markers. The need of validation and standardization of laboratory protocols is addressed and discussed as it may determine the comparison of data between different studies and laboratories, with relevance in field-collected samples or studies.
Authors:
A P Arez; V E do Rosário
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Transboundary and emerging diseases     Volume:  55     ISSN:  1865-1674     ISO Abbreviation:  Transbound Emerg Dis     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-31     Completed Date:  2008-09-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101319538     Medline TA:  Transbound Emerg Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  226-32     Citation Subset:  IM    
Affiliation:
Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Rua da Junqueira, 96, 1349-008 Lisbon, Portugal. aparez@ihmt.unl.pt
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MeSH Terms
Descriptor/Qualifier:
Animals
Diagnosis, Differential
Genetic Markers / genetics
Genetic Variation*
Humans
Malaria / diagnosis*,  veterinary
Plasmodium / classification,  genetics*,  isolation & purification
Public Health*
Sensitivity and Specificity
Species Specificity
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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