Document Detail

The relevance of fat content in toxicity of lipophilic chemicals to terrestrial animals with special reference to dieldrin and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
MedLine Citation:
PMID:  7691535     Owner:  NLM     Status:  MEDLINE    
Lipophilic chemicals such as chlorinated hydrocarbon insecticides and other persistent chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are fat soluble chemicals and are readily bioconcentrated in animal fat depots. The modifying role of the body fat content in the toxicity of chlorinated cyclodiene insecticides to insects and in the toxicity of TCDD to different mammals was investigated. The single oral acute 30-day LD50 data of TCDD in different mammals are presented and correlated with their total body fat content. A two linear regression equation with log/log values was obtained. It is concluded that the storage of TCDD and other related lipophilic and persistent chemicals in lipids of organisms is, in a sense, a detoxication mechanism by which the compounds are removed from sites of action and/or receptors. Therefore, terrestrial organisms such as insects and mammals with higher total body fat content can accumulate and tolerate higher chlorinated hydrocarbon insecticide and TCDD doses than organisms with lower fat content. The different sensitivity of mammals of various species, strains, body weight, sex, age, etc. to acute toxicity of TCDD and related lipophilic persistent chemicals can mainly be explained by differences in total body fat content.
H J Geyer; I Scheunert; K Rapp; I Gebefügi; C Steinberg; A Kettrup
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  26     ISSN:  0147-6513     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-11-09     Completed Date:  1993-11-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-60     Citation Subset:  IM    
GSF-Forschungszentrum für Umwelt und Gesundheit, GmbH, München, Germany.
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MeSH Terms
Adipose Tissue / metabolism*
Dieldrin / metabolism,  toxicity*
Insects / drug effects*,  metabolism
Lethal Dose 50
Mammals / metabolism*
Species Specificity
Tetrachlorodibenzodioxin / metabolism,  toxicity*
Reg. No./Substance:
1746-01-6/Tetrachlorodibenzodioxin; 60-57-1/Dieldrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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