Document Detail


The release of kininase from rat isolated hearts during myocardial ischaemia.
MedLine Citation:
PMID:  8856168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BK destroying activity was observed in rat isolated heart perfusates. BK was optimally degraded at pH 8.4 in rat heart. The results indicated that myocardial kinin degradation was due to ACE and a serine protease. These results suggest that bradykinin may have some cardioprotective role during myocardial ischaemia at acidic pH.
Authors:
M Ahmad; I J Zeitlin; J R Parratt
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Immunopharmacology     Volume:  33     ISSN:  0162-3109     ISO Abbreviation:  Immunopharmacology     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1997-02-10     Completed Date:  1997-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902474     Medline TA:  Immunopharmacology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  299-300     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland, UK.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Animals
Aprotinin / pharmacology
Bradykinin / metabolism
Captopril / pharmacology
Edetic Acid / pharmacology
Hydrogen-Ion Concentration
Lysine Carboxypeptidase / secretion*
Male
Myocardial Ischemia / enzymology*
Myocardium / enzymology*
Peptidyl-Dipeptidase A / secretion*
Perfusion
Rats
Rats, Sprague-Dawley
Serine Proteinase Inhibitors / pharmacology
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Serine Proteinase Inhibitors; 58-82-2/Bradykinin; 60-00-4/Edetic Acid; 62571-86-2/Captopril; 9087-70-1/Aprotinin; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.17.3/Lysine Carboxypeptidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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